Undifferentiated dementia, Alzheimer's disease and vascular dementia: age- and gender-related incidence in Liverpool. The MRC-ALPHA Study

Does incidence of dementia follow the age pattern of prevalence? Is gender a risk factor? Do patterns of incidence differ between dementias? To assess age-specific incidence rates of undifferentiated dementias, Alzheimer's disease and vascular dementia. 5222 individuals aged > or = 65 years,...

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Bibliographic Details
Published in:British journal of psychiatry 1999-11, Vol.175 (5), p.433-438
Main Authors: Copeland, JR, McCracken, CF, Dewey, ME, Wilson, KC, Doran, M, Gilmore, C, Scott, A, Larkin, BA
Format: Article
Language:English
Subjects:
Age
Age differences
Age distribution
Age Factors
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer's disease
Dementia
Dementia - diagnosis
Dementia - epidemiology
Dementia disorders
Dementia, Vascular - diagnosis
Dementia, Vascular - epidemiology
England - epidemiology
Etiology
Female
Gender
Health risk assessment
Health status
Humans
Incidence
Logistic Models
Male
Mental states
Neurodegenerative diseases
Neuropathology
Prevalence
Risk Factors
Sex Factors
Vascular dementia
Women
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Summary:Does incidence of dementia follow the age pattern of prevalence? Is gender a risk factor? Do patterns of incidence differ between dementias? To assess age-specific incidence rates of undifferentiated dementias, Alzheimer's disease and vascular dementia. 5222 individuals aged > or = 65 years, were interviewed using the Geriatric Mental State/History and Aetiology Schedule. The AGECAT package was used to identify cases at three interviewing waves at two-year intervals. Diagnoses were made using ICD-10 Research Criteria and validated against neurological and psychological examination, with imaging and neuropathology on unselected subsamples. Incidence rates of the dementias increase with age. Age patterns are similar between Alzheimer's disease and vascular dementia. Gender appears influential in Alzheimer's disease. In England and Wales, 39,437 new cases of Alzheimer's disease (4.9/1000 person-years at risk); 20,513 of vascular dementia (2.6/1000 person-years) and 155,169 of undifferentiated dementia (19/1000 person-years) can be expected each year. Incidence rates for Alzheimer's disease and vascular dementia appear to behave differently, with an increased risk of Alzheimer's disease for women compared to vascular dementia.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.175.5.433