An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia

SAP97 gene encodes the synaptic scaffolding PDZ proteins that interact with the l -alpha-amino-3-hydroxyl-5-methylisoxazole-4-propionate (AMPA), kainate and N -methyl- d -aspartate (NMDA) type glutamate receptors. Because the disturbed glutamate neurotransmission has been implicated in the pathophys...

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Bibliographic Details
Published in:Journal of Neural Transmission 2008-09, Vol.115 (9), p.1355-1365
Main Authors: Sato, Junko, Shimazu, Dai, Yamamoto, Naoki, Nishikawa, Toru
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adult
Basic Neurosciences
Brain - metabolism
Brain - physiopathology
Brain Chemistry - genetics
Case-Control Studies
DNA Mutational Analysis
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Genetic Testing
Genetics and Immunology - Original Article
Genotype
Haplotypes - genetics
Humans
Male
Medicine
Medicine & Public Health
Membrane Proteins - genetics
Middle Aged
Neurology
Neurosciences
Polymorphism, Single Nucleotide - genetics
Psychiatry
Receptors, Glutamate - metabolism
Schizophrenia - genetics
Schizophrenia - metabolism
Schizophrenia - physiopathology
Sex Distribution
Signal Transduction - genetics
Synaptic Membranes - genetics
Synaptic Membranes - metabolism
Synaptic Transmission - genetics
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Summary:SAP97 gene encodes the synaptic scaffolding PDZ proteins that interact with the l -alpha-amino-3-hydroxyl-5-methylisoxazole-4-propionate (AMPA), kainate and N -methyl- d -aspartate (NMDA) type glutamate receptors. Because the disturbed glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia, we investigated association between the SAP97 gene and schizophrenia. We genotyped 23 SNPs capturing the known common haplotype variations of the gene in a sample comprising 229 schizophrenic patients and 214 matched controls. In a single marker analysis, ten SNPs displayed nominally significant ( P  
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-008-0085-9