Novel pH-Responsive Nanoparticles

In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly(N-methacryloyl-l-valine) or poly(N-methacryloyl-l-phenylalanine), and nonionic surfactant (Brij 98) in the presenc...

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Bibliographic Details
Published in:Langmuir 2008-09, Vol.24 (17), p.9295-9301
Main Authors: Filippov, Sergey, Hrubý, Martin, Koňák, Čestmír, Macková, Hana, Špírková, Milena, Štěpánek, Petr
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams
Electrolytes
Exact sciences and technology
General and physical chemistry
Hydrogen-Ion Concentration
Ions
Light
Micelles
Micelles. Thin films
Microscopy, Atomic Force
Models, Chemical
Nanoparticles - chemistry
Nanotechnology - methods
Phenylalanine - chemistry
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Plant Oils - chemistry
Polyethylene Glycols - chemistry
Polymers - chemistry
Scattering, Radiation
Surface physical chemistry
Surface Properties
Valine - chemistry
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Summary:In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly(N-methacryloyl-l-valine) or poly(N-methacryloyl-l-phenylalanine), and nonionic surfactant (Brij 98) in the presence of hydrochloric acid. The influence of composition and pH on particles size and shape was investigated by a variety of methods. An entity’s size and polydispersity could be varied in a broad range making them a perspective candidate as a drug carrier. Unlike the case of typical micelles, our results indicate the presence of cavities in the formed particles. A hypothetical model of a nanoparticle and mechanism of formation are proposed.
ISSN:0743-7463
1520-5827
DOI:10.1021/la801472x