Night‐time work predisposes to non‐Hodgkin lymphoma

Our aim was to find out whether non‐Hodgkin lymphoma (NHL) was more common than expected among night‐time shift workers. The Finnish job‐exposure matrix (FINJEM) provided estimates of the proportion of exposed persons and the mean level of exposure among the exposed in each occupation. The probabili...

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Bibliographic Details
Published in:International journal of cancer 2008-11, Vol.123 (9), p.2148-2151
Main Authors: Lahti, Tuuli A., Partonen, Timo, Kyyrönen, Pentti, Kauppinen, Timo, Pukkala, Eero
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
circadian clock
Circadian Rhythm - physiology
Female
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - epidemiology
Lymphoma, Non-Hodgkin - etiology
Male
Medical sciences
Middle Aged
night‐time shift work
non‐Hodgkin lymphoma
Personnel Staffing and Scheduling
Risk
Sex Characteristics
Time Factors
Tumors
Work Schedule Tolerance
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Summary:Our aim was to find out whether non‐Hodgkin lymphoma (NHL) was more common than expected among night‐time shift workers. The Finnish job‐exposure matrix (FINJEM) provided estimates of the proportion of exposed persons and the mean level of exposure among the exposed in each occupation. The probability of night‐time work in each occupation was assessed, the observed and expected numbers of cancer cases in a cohort of persons born in 1906–1945 during the years of 1971–1995 were calculated, and the cumulative index of night‐time work was scored. The cohort compromised of 1,669,272 persons of whom 6,307 (3,813 men and 2,494 women) had NHL during the follow‐up. Night‐time work increased significantly (p = 0.01) the risk of NHL in men, the overall relative risk being 1.10 (95% confidence interval of 1.03–1.19). Using the lag period of 10 years, the risk ratio was 1.28 (1.03–1.59) for men who worked in night‐time shifts to a high degree as compared with those who had not been exposed to night‐time work. Night‐time workers are cancer prone and have a greater risk of NHL than population on average. © 2008 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.23566