Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Happy and sad emotion expressions in increasing int...

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Bibliographic Details
Published in:British journal of psychiatry 2008-09, Vol.193 (3), p.222-228
Main Authors: Lemche, Erwin, Anilkumar, Ananthapadmanabha, Giampietro, Vincent P., Brammer, Michael J., Surguladze, Simon A., Lawrence, Natalia S., Gasston, David, Chitnis, Xavier, Williams, Steven C. R., Sierra, Mauricio, Joraschky, Peter, Phillips, Mary L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Autonomic response
Brain
Brain mapping
Case-Control Studies
Central nervous system
Depersonalization
Depersonalization - diagnosis
Depersonalization - psychology
Emotions
Emotions - physiology
Facial Expression
Facial expressions
Female
Functional connectivity
Functional magnetic resonance imaging
Humans
Magnetic Resonance Imaging
Male
Measurement
Medical imaging
Medical research
Mental depression
Middle Aged
Neural networks
Neuroimaging
NMR
Nuclear magnetic resonance
Psychiatry
Stimulus
Suppression
Surveys and Questionnaires
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Description
Summary:Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses. Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4-6 s post-stimulus). The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.107.044263