Absolute Stereochemistry of Amphidinolide Q

The absolute configurations at five chiral centers in amphidinolide Q (1), a cytotoxic 12-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were elucidated to be 4R, 7R, 9S, 11R, and 13R on the basis of NMR analyses and a modified Mosher’s method.

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Bibliographic Details
Published in:Organic letters 2008-09, Vol.10 (17), p.3709-3711
Main Authors: Takahashi, Yohei, Kubota, Takaaki, Fukushi, Eri, Kawabata, Jun, Kobayashi, Jun’ichi
Format: Article
Language:English
Subjects:
Animals
Dinoflagellida - chemistry
Macrolides - chemistry
Models, Molecular
Molecular Conformation
Nuclear Magnetic Resonance, Biomolecular - methods
Stereoisomerism
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Summary:The absolute configurations at five chiral centers in amphidinolide Q (1), a cytotoxic 12-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were elucidated to be 4R, 7R, 9S, 11R, and 13R on the basis of NMR analyses and a modified Mosher’s method.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol8013123