Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide

The reaction between 2-hydrazinopyridine and ethylisothiocyanate produced 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide (HEPTS). Its reaction with copper fluoride, chloride, bromide, acetate, nitrate, perchlorate, sulfate, carbonate, hydroxide and copper metal produced 15 Cu(II) complexes. The copper m...

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Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2008-11, Vol.71 (1), p.73-79
Main Authors: Hassanien, M.M., Gabr, I.M., Abdel-Rhman, M.H., El-Asmy, A.A.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Biological activity
Chemistry, Pharmaceutical - methods
Copper - chemistry
Copper complexes
Drug Design
Electron Spin Resonance Spectroscopy - methods
Electronic spectra
ESR
Infrared
Ligands
Magnetic Resonance Spectroscopy
Magnetics
Metals - chemistry
Models, Chemical
Molecular Structure
Semicarbazides - analysis
Semicarbazides - chemistry
Spectrophotometry, Infrared - methods
Spectrophotometry, Ultraviolet - methods
Temperature
Thiosemicarbazide
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Summary:The reaction between 2-hydrazinopyridine and ethylisothiocyanate produced 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide (HEPTS). Its reaction with copper fluoride, chloride, bromide, acetate, nitrate, perchlorate, sulfate, carbonate, hydroxide and copper metal produced 15 Cu(II) complexes. The copper metal is easily oxidized in aqueous-ethanol solution of HEPTS giving [Cu 2(EPTS)(H 2O) 3(OH) 3]EtOH. Different complexes for the same anion were synthesized by controlling the heating time. Characterization by elemental, thermal, magnetic and spectral (electronic, IR, mass and ESR) studies showed the formation of mono-, di-, tri- and tetra nuclear complexes. The room temperature solid state ESR spectra of the complexes show an axial spectrum with d x 2 − y 2 ground state, suggesting distorted tetragonal geometry around Cu(II) center. The kinetic and thermodynamic parameters for the different decomposition steps in the complexes were calculated. HEPTS and its Cu(II) complexes showed high activity against gram negative bacteria; [Cu 3(EPTS) 2(EtOH) 2Br 4] has more activity.
ISSN:1386-1425
DOI:10.1016/j.saa.2007.11.009