Is the prognosis of heart failure improving?

• Published in: European journal of heart failure 1999-08, Vol.1 (3), p.229-241
• Main Authors: Cleland, John G.F., Gemmell, Islay, Khand, Aleem, Boddy, Andrew
• Format: Article
• Language: English
• Subjects: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Confidence Intervals; Epidemiology; Female; Heart failure; Heart Failure - drug therapy; Heart Failure - mortality; Hospital discharge; Hospital Mortality - trends; Humans; Length of Stay - statistics & numerical data; Length of Stay - trends; Male; Middle Aged; Patient Discharge - statistics & numerical data; Patient Discharge - trends; Patient Readmission - statistics & numerical data; Patient Readmission - trends; Prognosis; Progress; Retrospective Studies; Scotland - epidemiology
• ISSN: 1388-9842; 1879-0844
• DOI: 10.1016/S1388-9842(99)00032-X

Background and Methods. Heart failure is common and effective therapy exists but as yet there is little evidence that the overall prognosis is improving in clinical practice. We sought to determine if mortality, re‐admission with heart failure and re‐admission for any cause, had changed between cohorts of first‐time admissions for heart failure identified in 1984, 1988 and 1992 using linked hospital discharge and mortality data from Scotland (population approximately 5 million). Findings. The number of first‐time admissions for heart failure increased by 30% between 1984 and 1992, from 9716 to 12640. Their mean age was 74 years and 54% were women. Over the same period 3‐year mortality declined in patients < 65 years from 53 to 41% (reduction in risk 12% (95% confidence interval 9–15%. Log‐rank 70.0; P < 0.001) and for patients ≥ 65 years from 71% to 66% (reduction in risk 5% (95% confidence interval 3–6%. Log‐rank 74.5; P < 0.0001). Time to death or first re‐admission with heart failure also improved but not time to death or first re‐admission for any cause. The total number of re‐admissions increased between 1984 and 1992 but bed‐days occupancy for heart failure and for any cause, adjusted for days alive, declined due to a reduction in length of stay. Interpretation. These data suggest that the prognosis of patients with a first admission for heart failure is improving. The timing of improvement coincides with the gradual increase in the use of angiotensin converting enzyme inhibitors for heart failure although a causal link cannot be proved from these data.