Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes

Summary Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes. Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 1999-07, Vol.1 (4), p.227-232
Main Authors: Hermann, L. S., Ranstam, J., Vaaler, S., Melander, A.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Blood Glucose - metabolism
Blood Pressure
Body Mass Index
Cardiovascular Diseases - epidemiology
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - physiopathology
Diet, Diabetic
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Female
glibenclamide
Glyburide - therapeutic use
Humans
Hypoglycemic Agents - therapeutic use
Insulin - blood
Male
metformin
Metformin - therapeutic use
Middle Aged
Observer Variation
proinsulin
Proinsulin - blood
Risk Factors
Triglycerides - blood
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Summary:Summary Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes. Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7 mmol/l, were recruited from five diabetes outpatient clinics in primary health care. Diet and antihyperglycaemic medication, aiming at FBG
ISSN:1462-8902
1463-1326
DOI:10.1046/j.1463-1326.1999.00034.x