Loading…
Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes
Summary Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes. Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7...
Saved in:
| Published in: | Diabetes, obesity & metabolism obesity & metabolism, 1999-07, Vol.1 (4), p.227-232 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3 |
| container_end_page | 232 |
| container_issue | 4 |
| container_start_page | 227 |
| container_title | Diabetes, obesity & metabolism |
| container_volume | 1 |
| creator | Hermann, L. S. Ranstam, J. Vaaler, S. Melander, A. |
| description | Summary
Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes.
Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7 mmol/l, were recruited from five diabetes outpatient clinics in primary health care. Diet and antihyperglycaemic medication, aiming at FBG |
| doi_str_mv | 10.1046/j.1463-1326.1999.00034.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69506445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69506445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS0EoqXwCsgrdkn9FzuW2KBpaalaugHBznKca-ppJhlsh868AY-NpzMqCzasfOXznXvtcxHClNSUCHm6rKmQvKKcyZpqrWtCCBf15hk6fhKeP9asajVhR-hVSssCCd6ql-iIUsZa1bTH6Pe59-BywpPHdszhbruG-GPYOgur4HC-g2jXAYo-4nWcwpjmIYwF7XGEweZQ7jvIDwD_6M7GPky_bHLzYCOOId1jb12eYsIFyWUSZrgPtvghvUYvvB0SvDmcJ-jrx_Mvi8vq-vbi0-LDdeUEYaLqys-sBt8zzUjXK-is1VR6T1kjveSWe8e0UlpzxZRzndCeWAJSSk9UC_wEvdv3La_9OUPKZhWSg2GwI0xzMlI3RArRFLDdgy5OKUXwZh3DysatocTstmCWZhe22YVtdlswj1swm2J9e5gxdyvo_xoPsRfg_R54CANs_7uxObu9KUWxV3t7SBk2T3Yb741UXDXm2-cLc3a1aOTiOzOa_wHi4Kg7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69506445</pqid></control><display><type>article</type><title>Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes</title><source>Wiley</source><creator>Hermann, L. S. ; Ranstam, J. ; Vaaler, S. ; Melander, A.</creator><creatorcontrib>Hermann, L. S. ; Ranstam, J. ; Vaaler, S. ; Melander, A.</creatorcontrib><description>Summary
Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes.
Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7 mmol/l, were recruited from five diabetes outpatient clinics in primary health care. Diet and antihyperglycaemic medication, aiming at FBG <6.7 mmol/l, was maintained for 6 months after completed dose titration in a randomized, double‐blind, double‐dummy trial with metformin (M), glibenclamide (G) and primary combination of both drugs (MG). The study compared M, G and MG in low dose (MGL) and also different high‐dose regimens, i.e. G added to M (M/G), M added to G (G/M) and primary combination (MGH). Outcome measures were fasting proinsulin, glycaemia, body mass index, blood pressure, lipids, insulin and C‐peptide.
Results: Lower proinsulin levels were found when therapy was initiated with metformin (M vs. G, p = 0.013 and M/G vs. G/M, p = 0.033). M and G were equally effective on glucose levels. In the group as a whole FBG decreased from (mean ± s.d.) 10.2 ± 2.7 to 7.0 ± 1.2 mmol/l with no change in proinsulin. Proinsulin was associated with cardiovascular risk factors, linking high proinsulin to an atherogenic risk marker profile. Mean proinsulin change from baseline was inconsistently associated with markers of insulin resistance. Meal‐stimulated glucose (net AUC) decreased after treatment only in those with low baseline proinsulin levels.
Conclusion: It may be advantageous to initiate oral antihyperglycaemic therapy with metformin rather than with sulphonylurea. High proinsulin levels are associated with an atherogenic‐risk marker profile and an impaired therapeutic postprandial glucose response after treatment in patients with type 2 diabetes. Proinsulin change after therapy is inconsistently associated with markers of insulin resistance and unrelated to fasting blood glucose reduction.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1046/j.1463-1326.1999.00034.x</identifier><identifier>PMID: 11228758</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biomarkers - blood ; Blood Glucose - metabolism ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases - epidemiology ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - physiopathology ; Diet, Diabetic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Therapy, Combination ; Female ; glibenclamide ; Glyburide - therapeutic use ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - blood ; Male ; metformin ; Metformin - therapeutic use ; Middle Aged ; Observer Variation ; proinsulin ; Proinsulin - blood ; Risk Factors ; Triglycerides - blood</subject><ispartof>Diabetes, obesity & metabolism, 1999-07, Vol.1 (4), p.227-232</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3</citedby><cites>FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11228758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hermann, L. S.</creatorcontrib><creatorcontrib>Ranstam, J.</creatorcontrib><creatorcontrib>Vaaler, S.</creatorcontrib><creatorcontrib>Melander, A.</creatorcontrib><title>Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Summary
Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes.
Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7 mmol/l, were recruited from five diabetes outpatient clinics in primary health care. Diet and antihyperglycaemic medication, aiming at FBG <6.7 mmol/l, was maintained for 6 months after completed dose titration in a randomized, double‐blind, double‐dummy trial with metformin (M), glibenclamide (G) and primary combination of both drugs (MG). The study compared M, G and MG in low dose (MGL) and also different high‐dose regimens, i.e. G added to M (M/G), M added to G (G/M) and primary combination (MGH). Outcome measures were fasting proinsulin, glycaemia, body mass index, blood pressure, lipids, insulin and C‐peptide.
Results: Lower proinsulin levels were found when therapy was initiated with metformin (M vs. G, p = 0.013 and M/G vs. G/M, p = 0.033). M and G were equally effective on glucose levels. In the group as a whole FBG decreased from (mean ± s.d.) 10.2 ± 2.7 to 7.0 ± 1.2 mmol/l with no change in proinsulin. Proinsulin was associated with cardiovascular risk factors, linking high proinsulin to an atherogenic risk marker profile. Mean proinsulin change from baseline was inconsistently associated with markers of insulin resistance. Meal‐stimulated glucose (net AUC) decreased after treatment only in those with low baseline proinsulin levels.
Conclusion: It may be advantageous to initiate oral antihyperglycaemic therapy with metformin rather than with sulphonylurea. High proinsulin levels are associated with an atherogenic‐risk marker profile and an impaired therapeutic postprandial glucose response after treatment in patients with type 2 diabetes. Proinsulin change after therapy is inconsistently associated with markers of insulin resistance and unrelated to fasting blood glucose reduction.</description><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diet, Diabetic</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>glibenclamide</subject><subject>Glyburide - therapeutic use</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>metformin</subject><subject>Metformin - therapeutic use</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>proinsulin</subject><subject>Proinsulin - blood</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS0EoqXwCsgrdkn9FzuW2KBpaalaugHBznKca-ppJhlsh868AY-NpzMqCzasfOXznXvtcxHClNSUCHm6rKmQvKKcyZpqrWtCCBf15hk6fhKeP9asajVhR-hVSssCCd6ql-iIUsZa1bTH6Pe59-BywpPHdszhbruG-GPYOgur4HC-g2jXAYo-4nWcwpjmIYwF7XGEweZQ7jvIDwD_6M7GPky_bHLzYCOOId1jb12eYsIFyWUSZrgPtvghvUYvvB0SvDmcJ-jrx_Mvi8vq-vbi0-LDdeUEYaLqys-sBt8zzUjXK-is1VR6T1kjveSWe8e0UlpzxZRzndCeWAJSSk9UC_wEvdv3La_9OUPKZhWSg2GwI0xzMlI3RArRFLDdgy5OKUXwZh3DysatocTstmCWZhe22YVtdlswj1swm2J9e5gxdyvo_xoPsRfg_R54CANs_7uxObu9KUWxV3t7SBk2T3Yb741UXDXm2-cLc3a1aOTiOzOa_wHi4Kg7</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Hermann, L. S.</creator><creator>Ranstam, J.</creator><creator>Vaaler, S.</creator><creator>Melander, A.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes</title><author>Hermann, L. S. ; Ranstam, J. ; Vaaler, S. ; Melander, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diet, Diabetic</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>glibenclamide</topic><topic>Glyburide - therapeutic use</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>metformin</topic><topic>Metformin - therapeutic use</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>proinsulin</topic><topic>Proinsulin - blood</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermann, L. S.</creatorcontrib><creatorcontrib>Ranstam, J.</creatorcontrib><creatorcontrib>Vaaler, S.</creatorcontrib><creatorcontrib>Melander, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermann, L. S.</au><au>Ranstam, J.</au><au>Vaaler, S.</au><au>Melander, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>1999-07</date><risdate>1999</risdate><volume>1</volume><issue>4</issue><spage>227</spage><epage>232</epage><pages>227-232</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Summary
Aim: To assess the effect of oral antihyperglycaemic therapy on fasting proinsulin and the relation between proinsulin levels and cardiovascular risk factors in type 2 diabetes.
Methods: One hundred and sixty‐five patients with type 2 diabetes, fasting blood glucose concentration (FBG) ≥ 6.7 mmol/l, were recruited from five diabetes outpatient clinics in primary health care. Diet and antihyperglycaemic medication, aiming at FBG <6.7 mmol/l, was maintained for 6 months after completed dose titration in a randomized, double‐blind, double‐dummy trial with metformin (M), glibenclamide (G) and primary combination of both drugs (MG). The study compared M, G and MG in low dose (MGL) and also different high‐dose regimens, i.e. G added to M (M/G), M added to G (G/M) and primary combination (MGH). Outcome measures were fasting proinsulin, glycaemia, body mass index, blood pressure, lipids, insulin and C‐peptide.
Results: Lower proinsulin levels were found when therapy was initiated with metformin (M vs. G, p = 0.013 and M/G vs. G/M, p = 0.033). M and G were equally effective on glucose levels. In the group as a whole FBG decreased from (mean ± s.d.) 10.2 ± 2.7 to 7.0 ± 1.2 mmol/l with no change in proinsulin. Proinsulin was associated with cardiovascular risk factors, linking high proinsulin to an atherogenic risk marker profile. Mean proinsulin change from baseline was inconsistently associated with markers of insulin resistance. Meal‐stimulated glucose (net AUC) decreased after treatment only in those with low baseline proinsulin levels.
Conclusion: It may be advantageous to initiate oral antihyperglycaemic therapy with metformin rather than with sulphonylurea. High proinsulin levels are associated with an atherogenic‐risk marker profile and an impaired therapeutic postprandial glucose response after treatment in patients with type 2 diabetes. Proinsulin change after therapy is inconsistently associated with markers of insulin resistance and unrelated to fasting blood glucose reduction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11228758</pmid><doi>10.1046/j.1463-1326.1999.00034.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-8902 |
| ispartof | Diabetes, obesity & metabolism, 1999-07, Vol.1 (4), p.227-232 |
| issn | 1462-8902 1463-1326 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69506445 |
| source | Wiley |
| subjects | Biomarkers - blood Blood Glucose - metabolism Blood Pressure Body Mass Index Cardiovascular Diseases - epidemiology Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diet, Diabetic Dose-Response Relationship, Drug Double-Blind Method Drug Therapy, Combination Female glibenclamide Glyburide - therapeutic use Humans Hypoglycemic Agents - therapeutic use Insulin - blood Male metformin Metformin - therapeutic use Middle Aged Observer Variation proinsulin Proinsulin - blood Risk Factors Triglycerides - blood |
| title | Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T15%3A48%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20antihyperglycaemic%20therapies%20on%20proinsulin%20and%20relation%20between%20proinsulin%20and%20cardiovascular%20risk%20factors%20in%20type%202%20diabetes&rft.jtitle=Diabetes,%20obesity%20&%20metabolism&rft.au=Hermann,%20L.%20S.&rft.date=1999-07&rft.volume=1&rft.issue=4&rft.spage=227&rft.epage=232&rft.pages=227-232&rft.issn=1462-8902&rft.eissn=1463-1326&rft_id=info:doi/10.1046/j.1463-1326.1999.00034.x&rft_dat=%3Cproquest_cross%3E69506445%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4024-b326a9efd2920bd7ebaa916ff1256f63a3fc2977993727ccb49f0a0e666f078e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69506445&rft_id=info:pmid/11228758&rfr_iscdi=true |