Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis

Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen...

Full description

Saved in:
Bibliographic Details
Published in:Mycopathologia (1975) 1999-11, Vol.148 (2), p.79-82
Main Authors: YANG, Depo, MICHEL, Laura, CHAUMONT, Jean-Pierre, MILLET-CLERC, Joëlle
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - therapeutic use
Biological and medical sciences
caryophyllene oxide
Ciclopirox
Experimental mycoses and models
Fundamental and applied biological sciences. Psychology
Hoof and Claw - drug effects
Hoof and Claw - microbiology
Humans
Imidazoles - therapeutic use
Infectious diseases
Medical sciences
Microbiology
Mycoses
Onychomycosis - drug therapy
Onychomycosis - microbiology
Pharmacology. Drug treatments
Pyridones - therapeutic use
Sesquiterpenes - therapeutic use
Sheep
terpenoids
Trichophyton - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen because of their very different chemical structures. So, a new model has been tested, utilizing sheep hoof plates in order to simulate human nails, which are almost unobtainable for in vitro tests. Three protocols were utilized: pre-treatment, simultaneous treatment and post-treatment. Among these, the post-treatment method was the best to simulate antifungal therapy, as it permitted testing and comparing the efficiency of different antifungal drugs.
ISSN:0301-486X
1573-0832
DOI:10.1023/A:1007178924408