Soft Tissue and Epithelial Models

• Published in: Advances in dental research 1999-06, Vol.13 (1), p.57-66
• Main Authors: Jansen, J.A., Den Braber, E.T., Walboomers, X.F., De Ruijter, J.E.
• Format: Article
• Language: English
• Subjects: Alveolar Process - cytology; Biocompatible Materials - chemistry; Cell Adhesion - physiology; Chemical Phenomena; Chemistry, Physical; Dental Implants; Dental Materials - chemistry; Dentistry; Epithelial Cells - physiology; Fibroblasts - physiology; Gingiva - cytology; Humans; Image Processing, Computer-Assisted; Microscopy, Confocal; Microscopy, Electron; Mouth Mucosa - cytology; Mouth Mucosa - physiology; Surface Properties
• ISSN: 0895-9374; 1544-0737
• DOI: 10.1177/08959374990130011601

The applicability of a biomaterial for the manufacturing of oral implants is determined by its physicochemical and geometric surface properties. Research, therefore, is concerned with the cellular reactions that occur when an implant material comes into contact with body tissues. For permucosal oral implants, this involves both the reaction of bone and gingival cells. In vitro cell culturing-including the use of various analytical techniques like light microscopy, scanning and transmission electron microscopy, confocal laser scanning microscopy, and digital image analysis-is a good tool whereby investigators can obtain more insight into the relevant components of implant-tissue adhesion. In the current overview, the role of cell models in oral implant research is discussed, specifically with reference to responses of epithelial cells and fibroblasts.