Tuberculosis isolated to the renal allograft

: Immunosuppressed patients after renal transplantation are at increased risk of developing infective complications, including tuberculosis. We describe four renal transplant patients who presented with tuberculosis isolated to the renal allograft. The three patients with adequate follow‐up presente...

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Bibliographic Details
Published in:Transplant infectious disease 1999-03, Vol.1 (1), p.83-86
Main Authors: Lorimer, I., Botha, J., Pontin, A.R., Pascoe, M.D., Kahn, D.
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents
Antitubercular Agents - therapeutic use
Biopsy, Needle
Drug Therapy, Combination - therapeutic use
endemic area
Female
Humans
Kidney Transplantation - pathology
Male
Nephrectomy
Postoperative Complications
renal allograft
Reoperation
Transplantation, Homologous
tuberculosis
Tuberculosis - drug therapy
Tuberculosis - pathology
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Summary:: Immunosuppressed patients after renal transplantation are at increased risk of developing infective complications, including tuberculosis. We describe four renal transplant patients who presented with tuberculosis isolated to the renal allograft. The three patients with adequate follow‐up presented with a febrile illness 12–26 months after the transplant. The mycobacterial infection was found in the graft nephrectomy specimen in three patients. One patient with renal allograft dysfunction had a percutaneous biopsy that showed tuberculosis. The latter patient recovered renal allograft function after anti‐tuberculous therapy. None of the patients had evidence of tuberculosis elsewhere. We conclude that tuberculosis isolated to the renal allograft, especially in an endemic area, may be the cause of renal dysfunction, and appropriate therapy could lead to salvage of the graft.
ISSN:1398-2273
1399-3062
DOI:10.1034/j.1399-3062.1999.10109.x