Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery

Objective The interval between induction and delivery may change in association with different polymorphisms in genes regulating inflammation. Study Design Seventy participants in a trial for induction of labor at term were tested for a −765 G>C cyclooxygenase-2 and an intron 2 length interleukin...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2008-09, Vol.199 (3), p.296.e1-296.e5
Main Authors: Skupski, Daniel W., MD, Normand, Neil, MS, Eglinton, Gary S., MD, Witkin, Steven S., PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
cervical ripening
Cervical Ripening - physiology
cyclooxygenase
Cyclooxygenase 2 - genetics
Delivery. Postpartum. Lactation
Female
Gene Frequency
genetic polymorphisms
Gynecology. Andrology. Obstetrics
Humans
interleukin
Interleukin 1 Receptor Antagonist Protein - genetics
labor
labor induction
Labor, Induced
Medical sciences
Obstetrics and Gynecology
Oligohydramnios - therapy
Polymorphism, Genetic
Pregnancy
Time Factors
Trial of Labor
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Summary:Objective The interval between induction and delivery may change in association with different polymorphisms in genes regulating inflammation. Study Design Seventy participants in a trial for induction of labor at term were tested for a −765 G>C cyclooxygenase-2 and an intron 2 length interleukin-1 receptor antagonist gene polymorphism. Results The interleukin-1 receptor antagonist allele 2 frequency was 33.3% in the 12 women who delivered at ≤10 hours, compared with 13.8% in those delivered >10 hours ( P = .03). The interleukin-1 receptor antagonist allele 2 frequency was 25.0% in women induced because of postdates as opposed to 7.9% induced for other indications ( P = .01). The cyclooxygenase-2 allele C frequency was 30.0% in 35 women delivered at ≤20 hours as opposed to 11.4% in women delivered at >20 hours ( P = .01). The cyclooxygenase-2 allele C frequency was 26.9% in 26 subjects induced because of postdates as opposed to 13.6% induced for other indications ( P = .07). Conclusion Cyclooxygenase-2 allele C and interleukin-1 receptor antagonist allele 2 are associated with a reduced time interval from labor induction to delivery.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2008.06.063