Genetic engineering of doxorubicin production in Streptomyces peucetius : a review

The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.

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Bibliographic Details
Published in:Journal of industrial microbiology & biotechnology 1999-07, Vol.23 (1), p.647-652
Main Authors: HUTCHINSON, C. R, COLOMBO, A. L
Format: Article
Language:English
Subjects:
Antibiotics
Antineoplastic Agents - metabolism
Antineoplastic drugs. Cytokines
Biochemistry
Biological and medical sciences
Biosynthesis
Biotechnology
Carbon
Daunorubicin - biosynthesis
Daunorubicin - metabolism
DNA methylation
Doxorubicin - biosynthesis
E coli
Enzymes
Fundamental and applied biological sciences. Psychology
Genes
Genetic engineering
Genetic Engineering - methods
Genetics
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Oxidation
Pharmacy
Production of active biomolecules
Proteins
Streptomyces - metabolism
Streptomyces peucetius
Studies
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Description
Summary:The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.
ISSN:1367-5435
1476-5535
DOI:10.1038/sj.jim.2900673