Influence of sodium monoketocholate on the hypolipidemic activity of lovastatin in healthy and diabetic rats

Summary Recent findings regarding the physiological transport mechanisms and metabolism of bile acids have led to an increased interest in their synthetic derivatives, especially as transmucous transporters. The aim of this study was to examine the influence of the synthetic sodium salt of monoketoc...

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Published in:European journal of drug metabolism and pharmacokinetics 2008-04, Vol.33 (2), p.77-84
Main Authors: Kojic-Damjanov, Suncica, Djeric, Mirjana, Mikov, Momir, Kuhajda, Ksenija, Kevresan, Slavko
Format: Article
Language:English
Subjects:
Animals
Anticholesteremic Agents - pharmacology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood Glucose - metabolism
Chenodeoxycholic Acid - analogs & derivatives
Chenodeoxycholic Acid - pharmacology
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diabetes Mellitus, Experimental - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Human Physiology
Lipids - blood
Lovastatin - pharmacology
Male
Medical Biochemistry
Medical sciences
Pharmaceutical Sciences/Technology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Wistar
Triglycerides - blood
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Summary:Summary Recent findings regarding the physiological transport mechanisms and metabolism of bile acids have led to an increased interest in their synthetic derivatives, especially as transmucous transporters. The aim of this study was to examine the influence of the synthetic sodium salt of monoketocholic acid (Na-MKHA) on the hypolipidemic activity of lovastatin. The effects of a 7 days administration of lovastatin (20 mg/kg b.w.) (experimental group 1, n =5) and a combination of lovastatin (20 mg/kg b.w.) and Na-MKHA (2 mg/kg b.w.) (experimental group 2, n =5) in group of healthy and diabetic male Wistar rats were investigated. The animals in the control group of healthy ( n =5) and diabetic ( n =5) rats were treated with physiological saline (10 ml/kg b.w.) per os twice a day. In the healthy rats, lovastatin increased the low density lipoprotein (LDL) (32.14%) and non-high density lipoprotein (HDL) (15.38%) cholesterol and decreased HDL cholesterol levels (9.89%), and also increased the investigated atherogenic ratios. Na-MKHA significantly potentiated lovastatin activity, and its effects on the LDL ( p
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03191024