Nanofiber Applications for Burn Care

Nanotechnology is a growing field of manufactured materials with sizes less than 1 mum, and it is particularly useful in the field of medicine because these applications replicate components of a cell's in vivo environment. Nanofibers, which mimic collagen fibrils in the extracellular matrix (E...

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Bibliographic Details
Published in:Journal of burn care & research 2008-09, Vol.29 (5), p.695-703
Main Authors: HROMADKA, Michael, COLLINS, James B, REED, Courtney, LI HAN, KOLAPPA, Kamal K, CAIRNS, Bruce A, ANDRADY, Tony, VAN AALST, John A
Format: Article
Language:English
Subjects:
Analgesics - therapeutic use
Anti-Bacterial Agents - therapeutic use
Antitubercular Agents - therapeutic use
Biocompatible Materials - therapeutic use
Biological and medical sciences
Burns
Burns - drug therapy
Burns - therapy
Cefazolin - therapeutic use
Cell Adhesion
Cell Movement
Cell Proliferation
Coagulants - therapeutic use
Collagen - therapeutic use
Dermatology
Extracellular Matrix Proteins - therapeutic use
Fibrinogen - therapeutic use
Fibromodulin
Humans
Medical sciences
Nanomedicine - methods
Nanostructures - therapeutic use
Platelet-Derived Growth Factor
Porosity
Proteoglycans - therapeutic use
Rifampin - therapeutic use
Transforming Growth Factor beta1 - drug effects
Traumas. Diseases due to physical agents
Wound Healing - drug effects
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Summary:Nanotechnology is a growing field of manufactured materials with sizes less than 1 mum, and it is particularly useful in the field of medicine because these applications replicate components of a cell's in vivo environment. Nanofibers, which mimic collagen fibrils in the extracellular matrix (ECM), can be created from a host of natural and synthetic compounds and have multiple properties that may be beneficial to burn wound care. These properties include a large surface-area-to-volume ratio, high porosity, improved cell adherence, proliferation and migration, and controlled in vivo degradation rates. The large surface area of nanofiber mats allows for increased interaction with compounds and provides a mechanism for sustained release of antibiotics, analgesics, or growth factors into burn wounds; high porosity allows diffusion of nutrients and waste. Improved cell function on these scaffolds will promote healing. Controlled degradation rates of these scaffolds will promote scaffold absorption after its function is no longer required. The objective of this article is to review the current literature describing nanofibers and their potential application to burn care.
ISSN:1559-047X
1559-0488
DOI:10.1097/BCR.0b013e31818480c9