Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population

• Published in: Neuroscience letters 2008-10, Vol.444 (1), p.109-111
• Main Authors: Zhou, Yong-Tao, Zhang, Zhen-Xin, Chan, Piu, He, Xiao-Ming, Tang, Mou-Ni, Wu, Cheng-Bin, Hong, Zhen
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer's disease; Asian Continental Ancestry Group - ethnology; Biological and medical sciences; Confidence Intervals; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease-Free Survival; Female; Fundamental and applied biological sciences. Psychology; Gene Frequency; Genetic Predisposition to Disease - genetics; Genotype; Humans; Low Density Lipoprotein Receptor-Related Protein-1 - genetics; Low-density lipoprotein receptor-related protein; Male; Medical sciences; Middle Aged; Neurology; Odds Ratio; Polymorphism; Polymorphism, Genetic - genetics; Vertebrates: nervous system and sense organs
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2008.07.093

Alzheimer's disease (AD) is the most common neurodegenerative disorders in the elderly. Low-density lipoprotein receptor-related protein (LRP), as a receptor of apolipoprotein E (APOE), APP, and alpha2 macroglobulin (α2-M), keeps the balance between degeneration and production of beta-amyloid protein (Aβ) clearance. Its gene had been defined as a candidate gene for AD, but the results were not universal. Total 496 AD patients and 478 controls were recruited in Chinese Han population and real-time PCR was used to detect the polymorphism of LRP C766T. Multiple logistic regression, Chi-square test and survival analysis were performed to explore the association. The distribution of LRP genotypes and alleles was significantly different between cases and controls, and T allele could reduce the risk for developing AD (OR of CT genotype: 0.57; 95% CI: 0.38–0.85, ρ = 0.003; OR of T allele: 0.57; 95% CI: 0.39–0.83, ρ = 0.003). TT genotype carriers had 5 years later for developing AD compared with CC genotype carriers, but survival analysis did not conform this (LRP TT vs. CT and CC log rank χ 2 = 2.71, ρ = 0.26). The distribution of LRP C766T genotypes and alleles was different among different severity stratified by MMSE yet ( ρ = 0.26). Our data suggested that the polymorphism of LRP C766T was strongly associated with AD and T allele might be a protective factor for AD in Chinese Han population.