Biological Basis of Bone Formation, Remodeling, and Repair-Part I: Biochemical Signaling Molecules

The bony biochemical environment is an active and dynamic system that permits and promotes cellular functions that lead to matrix production and ossification. Each component is capable of conveying important regulatory cues to nearby cells, thus effecting gene expression and changes at the cytostruc...

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Bibliographic Details
Published in:Tissue engineering. Part B, Reviews Reviews, 2008-09, Vol.14 (3), p.259-273
Main Authors: Allori, Alexander C., Sailon, Alexander M., Warren, Stephen M.
Format: Article
Language:English
Subjects:
Biochemistry
Bone and Bones - cytology
Bone and Bones - physiology
Bone Development - physiology
Bone Diseases - therapy
Bone regeneration
Bone Remodeling - physiology
Bones
Cell Cycle
Cell Differentiation
Cell Division
Cytokines - physiology
Gene expression
Genetic aspects
Growth Substances - physiology
Health aspects
Hormones - physiology
Humans
Insulin-Like Growth Factor I - physiology
Molecular biology
Original Papers
Physiological aspects
Signal Transduction
Tissue engineering
Transforming Growth Factor beta - physiology
Vascular Endothelial Growth Factor A - physiology
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Summary:The bony biochemical environment is an active and dynamic system that permits and promotes cellular functions that lead to matrix production and ossification. Each component is capable of conveying important regulatory cues to nearby cells, thus effecting gene expression and changes at the cytostructural level. Here, we review the various signaling molecules that contribute to the active and dynamic nature of the biochemical system. These components include hormones, cytokines, and growth factors. We describe their role in regulating bone metabolism. Certain growth factors (i.e., TGF-β, IGF-1, and VEGF) are described in greater detail because of their potential importance in developing successful tissue-engineering strategies.
ISSN:1937-3368
1937-3376
DOI:10.1089/ten.teb.2008.0082