Prevalence and risk factors of osteoporosis in patients with Parkinson’s disease

• Published in: Rheumatology international 2008-10, Vol.28 (12), p.1205-1209
• Main Authors: Bezza, A., Ouzzif, Z., Naji, H., Achemlal, L., Mounach, A., Nouijai, M., Bourazza, A., Mossadeq, R., El Maghraoui, A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Bone Density; Bones; Calcium, Dietary; Case-Control Studies; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Morocco - epidemiology; Original Paper; Osteoporosis; Osteoporosis - complications; Osteoporosis - epidemiology; Parkinson Disease - complications; Parkinson Disease - epidemiology; Prevalence; Rheumatology; Risk Factors; Sunlight
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-008-0632-6

Parkinson’s disease (PD) is the most common cause of disability in the elderly. It is currently recognized as a cause of secondary osteoporosis. To evaluate the prevalence of osteoporosis in PD and detect its risk factors, 52 patients with PD (36 men/16 women) and 52 controls paired for age and sex were recruited. Clinical data including demography, disease duration and disease severity were collected. All subjects had bone mineral density (BMD) measured by dual energy X-ray absorptiometry, dorsal and lumbar spine X-ray, and biological exams (osteocalcin, CTX, parathormon). The mean age of the patients was 60.0 ± 9.25 years [30–77], and the mean disease duration was 4.9 ± 4.5 years [0.2–17]. Nine patients (17.3%) were osteoporotic and 28 (53.8%) osteopenic. BMD at the lumbar spine and the hip was lower among patients than controls (spine: 1.031 vs. 1.175 g/cm 2 ; P