Short Synthesis of (−)-Cephalotaxine Using a Radical Cascade

The short total synthesis of (−)-cephalotaxine is described. The concise construction of the pentacyclic core of this alkaloid was achieved by a radical cascade involving 7-endo and 5-endo cyclizations.

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Bibliographic Details
Published in:Organic letters 2008-09, Vol.10 (18), p.4129-4131
Main Authors: Taniguchi, Tsuyoshi, Ishibashi, Hiroyuki
Format: Article
Language:English
Subjects:
Cyclization
Free Radicals - chemistry
Harringtonines - chemical synthesis
Harringtonines - chemistry
Stereoisomerism
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Description
Summary:The short total synthesis of (−)-cephalotaxine is described. The concise construction of the pentacyclic core of this alkaloid was achieved by a radical cascade involving 7-endo and 5-endo cyclizations.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol801747m