Preparation of Highly Photosensitizing Liposomes with Fullerene-Doped Lipid Bilayer Using Dispersion-Controllable Molecular Exchange Reactions

Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by...

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Bibliographic Details
Published in:Organic letters 2008-09, Vol.10 (18), p.4077-4080
Main Authors: Ikeda, Atsushi, Sue, Tatsuya, Akiyama, Motofusa, Fujioka, Katsuyoshi, Shigematsu, Tamami, Doi, Yuki, Kikuchi, Jun-ichi, Konishi, Toshifumi, Nakajima, Riichiro
Format: Article
Language:English
Subjects:
Cyclodextrins - chemistry
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Fullerenes - chemistry
Lipid Bilayers - chemistry
Liposomes - chemical synthesis
Liposomes - chemistry
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
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Summary:Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by heating and microwave irradiation. This result indicates that control of self-aggregation of fullerene leads to a high quantum yield for the photoreaction because of the suppression of self-quenching of photoexcited fullerenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol8015918