Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function

Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function Sebastiaan Hammer, Marieke Snel, Hildo J. Lamb, Ingrid M. Jazet, Rutger W. van der Meer, Hanno Pijl, Edo A. Meinders, Johannes A. Romijn, Albert de...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-09, Vol.52 (12), p.1006-1012
Main Authors: Hammer, Sebastiaan, MSc, Snel, Marieke, MD, Lamb, Hildo J., MD, PhD, Jazet, Ingrid M., MD, PhD, van der Meer, Rutger W., MD, Pijl, Hanno, MD, PhD, Meinders, Edo A., MD, PhD, Romijn, Johannes A., MD, PhD, de Roos, Albert, MD, PhD, Smit, Johannes W.A., MD, PhD
Format: Article
Language:English
Subjects:
Caloric Restriction
Cardiology
Cardiovascular
cardiovascular imaging
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diet therapy
Diabetes Mellitus, Type 2 - metabolism
Diastole
Female
Humans
Internal Medicine
Liver - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Myocardium - metabolism
Obesity
Obesity - complications
Obesity - diet therapy
Obesity - metabolism
Rodents
Spectrum analysis
Systole
triglycerides
Triglycerides - metabolism
type 2 diabetes mellitus
Ventricular Function, Left
Weight control
weight loss
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Summary:Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function Sebastiaan Hammer, Marieke Snel, Hildo J. Lamb, Ingrid M. Jazet, Rutger W. van der Meer, Hanno Pijl, Edo A. Meinders, Johannes A. Romijn, Albert de Roos, Johannes W. A. Smit In type 2 diabetes mellitus (T2DM), myocardial triglyceride (TG) stores are increased. We studied the effects of prolonged caloric restriction on myocardial TG content, myocardial function, and glucoregulation in obese patients with T2DM. Caloric restriction decreased body weight associated with improved glucoregulation, a decrease in myocardial TG content, and improvements in diastolic function. We conclude that myocardial TG stores in obese patients with T2DM are flexible and amendable to therapeutic intervention by caloric restriction. Therefore, the data emphasize the potential relevance of measuring myocardial TG content as a surrogate marker to assess the effects of metabolic interventions on the heart.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2008.04.068