Exercise enhances vaccine-induced antigen-specific T cell responses

Abstract Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal...

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Bibliographic Details
Published in:Vaccine 2008-10, Vol.26 (42), p.5407-5415
Main Authors: Rogers, Connie J, Zaharoff, David A, Hance, Kenneth W, Perkins, Susan N, Hursting, Stephen D, Schlom, Jeffrey, Greiner, John W
Format: Article
Language:English
Subjects:
Adaptive immunity
Allergy and Immunology
Animals
Applied microbiology
Biological and medical sciences
Body Composition
Cardiovascular disease
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cell growth
Cell Proliferation
Cytokines
Cytokines - biosynthesis
Cytokines - immunology
Exercise
Female
Fundamental and applied biological sciences. Psychology
Hypotheses
Immune response
Immune system
Influenza
Laboratory animals
Lymphocyte Activation - immunology
Lymphocytes
Mice
Mice, Inbred C57BL
Microbiology
Motor Activity
Ovalbumin - immunology
Studies
Substrate Specificity
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Abstract Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.07.081