Association of Vitamin D Receptor Genotype with Leprosy Type

Host genetic factors including major histocompatibility complex (MHC) polymorphisms influence both susceptibility to leprosy per se and also to leprosy type. Non-MHC genes may play an important role, but such genes remain undefined. The influence of two non-MHC candidate genes was assessed in a case...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-01, Vol.179 (1), p.187-191
Main Authors: Roy, S., Frodsham, A., Saha, B., Hazra, S. K., Mascie-Taylor, C. G. N., Hill, A.V. S.
Format: Article
Language:English
Subjects:
Alleles
Bacterial diseases
Base Sequence
Biological and medical sciences
Carrier Proteins - genetics
Case-Control Studies
Cation Transport Proteins
DNA Primers - genetics
Gene Frequency
Genetic Variation
Genotype
Genotypes
Human bacterial diseases
Human genetics
Humans
Immunogenetics
India
Infectious diseases
Leprosy
Leprosy - genetics
Leprosy - immunology
Leprosy, Lepromatous - genetics
Leprosy, Lepromatous - immunology
Leprosy, Tuberculoid - genetics
Leprosy, Tuberculoid - immunology
Macrophages
Major Articles
Medical sciences
Membrane Proteins - genetics
Mycobacterium tuberculosis
Polymerase chain reaction
Polymorphism, Genetic
Receptors
Receptors, Calcitriol - genetics
Receptors, Calcitriol - immunology
Sequence Deletion
Tropical bacterial diseases
Tuberculoid leprosy
Vitamin D
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Summary:Host genetic factors including major histocompatibility complex (MHC) polymorphisms influence both susceptibility to leprosy per se and also to leprosy type. Non-MHC genes may play an important role, but such genes remain undefined. The influence of two non-MHC candidate genes was assessed in a case-control study of Bengali leprosy patients from Calcutta. Recent studies have implicated variation in the vitamin D receptor (VDR) gene in susceptibility to several diseases, including osteoporosis and pulmonary tuberculosis. In this population, homozygotes for the alternate alleles of the VDR polymorphism are associated, respectively, with lepromatous and tuberculoid leprosy. The NRAMP1 (n atural resistance associated macrophage protein 1) gene may influence human mycobacterial disease susceptibility based on studies with the murine homologue Nramp1. However, no significant association was found between NRAMP1 and leprosy susceptibility. This study suggests that the VDR polymorphism may influence susceptibility to some diseases by affecting the type and the strength of the host immune response.
ISSN:0022-1899
1537-6613
DOI:10.1086/314536