Salivary histatins in patients with recurrent oral candidiasis

The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral candidiasis and in age‐, sex‐matched healthy controls. Salivary pH, flow rate, total protein and histatins were compared. Results of this study indicated that salivary pH was significantly lower among patie...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 1999-01, Vol.28 (1), p.26-29
Main Authors: Bercier, John G., Al-Hashimi, Ibtisam, Haghighat, Nasser, Rees, Terry D., Oppenheim, Frank G.
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - analysis
Aged
Biological and medical sciences
Biotechnology
Candida - growth & development
candidiasis
Candidiasis, Oral - metabolism
Case-Control Studies
Colony Count, Microbial
Dentistry
Female
Fundamental and applied biological sciences. Psychology
Genetic engineering
Genetic technics
Glycoproteins - analysis
histatins
Humans
Hydrogen-Ion Concentration
In vitro gene amplification. Pcr technique
Male
Methods. Procedures. Technologies
Middle Aged
Proteins - analysis
Recurrence
saliva
Saliva - physiology
Saliva - secretion
Salivary Proteins and Peptides - analysis
Secretory Rate
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Summary:The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral candidiasis and in age‐, sex‐matched healthy controls. Salivary pH, flow rate, total protein and histatins were compared. Results of this study indicated that salivary pH was significantly lower among patients than controls (5.9 vs 6.3, respectively, P=0.002). No significant difference was observed in the mean flow rate and total protein between patients and controls (0.39 ml/min/gland vs 0.46 ml/min/gland and 112.4 mg% vs 113.0 mg%, respectively). However, the mean salivary histatin levels were significantly higher among patients than controls, both in terms of concentration (16.8 mg% vs 11.1 mg%, P=0.016) as well as a ratio of total protein (15 mg/g vs 10 mg/g, P=0.018). These findings indicate that oral candidiasis is associated with increased levels of salivary histatin. Such a finding suggests that oral candidiasis may modulate the levels of salivary histatin.
ISSN:0904-2512
1600-0714
DOI:10.1111/j.1600-0714.1999.tb01990.x