Effects of ultrasound-assisted compaction on Ketoprofen/Eudragit® S100 Mixtures

• Published in: European journal of pharmaceutical sciences 1999-02, Vol.7 (3), p.207-213
• Main Authors: Sancin, Pietro, Caputo, Otto, Cavallari, Cristina, Passerini, Nadia, Rodriguez, Lorenzo, Cini, Maurizio, Fini, Adamo
• Format: Article
• Language: English
• Subjects: Acrylic Resins - chemistry; Amorphous state; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Biological and medical sciences; Differential thermal analysis; Drug Compounding; Eudragit® S100; Excipients - chemistry; General pharmacology; Ketoprofen; Ketoprofen - chemistry; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymethacrylic Acids; Tablets; Ultrasonics; Ultrasound compaction
• ISSN: 0928-0987; 1879-0720
• DOI: 10.1016/S0928-0987(98)00022-0

Ketoprofen alone and in binary mixtures with Eudragit® S100 was compacted by an ultrasound-assisted (US) tableting machine at an energy ranging from 50 to 400 J. The final material was analysed by TLC and HPLC: no decomposition product of the active agent was found. IR spectra and HSM revealed the absence of any interaction between the two components. Thermal analysis (DSC) evidenced that ketoprofen inside the mixtures was transformed into an amorphous state, documented by the decreasing of the ΔH fus as the Eudragit®/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit® was found to slow down or possibly to prevent the regeneration of the crystallinity.