Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain

Ig-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduct...

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Bibliographic Details
Published in:The Journal of immunology (1950) 1999-01, Vol.162 (1), p.5-8
Main Authors: Nakajima, H, Samaridis, J, Angman, L, Colonna, M
Format: Article
Language:English
Subjects:
Animals
Cell Lineage - immunology
Cells, Cultured
Granulocytes - metabolism
Humans
Immunoglobulins - metabolism
Leukemia, Basophilic, Acute
Macrophage Activation
Membrane Glycoproteins - biosynthesis
Mice
Molecular Weight
Monocytes - immunology
Monocytes - metabolism
Rats
Rats, Wistar
Receptors, IgG - metabolism
Receptors, Immunologic - biosynthesis
Receptors, Immunologic - physiology
Signal Transduction - immunology
Tumor Cells, Cultured
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Description
Summary:Ig-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been observed in activating NK cell receptors and FcalphaR, which transduce stimulatory signals via associated DAP12 and FcepsilonRIgamma proteins, respectively. Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcepsilonRIgamma rather than DAP12.
ISSN:0022-1767