The Structure of Mithramycin Reinvestigated

A reinvestigation of the structure of mithramycin, the principal product of Streptomyces argillaceus ATCC 12956, is reported. The structure elucidation was carried out with mithramycin decaacetate (4) using 2D NMR methods, including TOCSY, HMBC, and HSQC experiments. The work resulted in structure 3...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-01, Vol.62 (1), p.119-121
Main Authors: Wohlert, S. E, Künzel, E, Machinek, R, Méndez, C, Salas, J. A, Rohr, J
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
ANTIBIOTICOS
ANTIBIOTICS
Antibiotics, Antineoplastic - chemistry
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
ANTIBIOTIQUE
ANTINEOPLASTIC AGENTS
Applied microbiology
Biological and medical sciences
Carbohydrate Sequence
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
Chemotherapic agents
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CYTOTOXIC COMPOUNDS
ESPECTROMETRIA
ESTRUCTURA QUIMICA
Fundamental and applied biological sciences. Psychology
GENERO HUMANO
GENRE HUMAIN
Magnetic Resonance Spectroscopy
MANKIND
MEDICAMENT CYTOSTATIQUE
Microbiology
Molecular Sequence Data
Molecular Structure
Plicamycin - chemistry
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STREPTOMYCES
Streptomyces argillaceus
STRUCTURE CHIMIQUE
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
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Summary:A reinvestigation of the structure of mithramycin, the principal product of Streptomyces argillaceus ATCC 12956, is reported. The structure elucidation was carried out with mithramycin decaacetate (4) using 2D NMR methods, including TOCSY, HMBC, and HSQC experiments. The work resulted in structure 3 being confirmed for mithramycin.
ISSN:0163-3864
1520-6025
DOI:10.1021/np980355k