Changes in left ventricular diastolic function 6 months after nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy

Nonsurgical septal reduction therapy (NSRT) decreases left ventricular outflow tract (LVOT) gradient and improves symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). NSRT effects on LV/left ventricular diastolic function are currently unknown. HOCM patients (n=29) had Doppler e...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1999-01, Vol.99 (3), p.344-347
Main Authors: NAGUEH, S. F, LAKKIS, N. M, MIDDLETON, K. J, KILLIP, D, ZOGHBI, W. A, QUINONES, M. A, SPENCER, W. H
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - physiopathology
Cardiomyopathy, Hypertrophic - therapy
Diastole - physiology
Diseases of the cardiovascular system
Echocardiography
Female
Follow-Up Studies
Heart Septum - physiology
Humans
Male
Medical sciences
Middle Aged
Mitral Valve - physiology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Ventricular Function, Left - physiology
Ventricular Outflow Obstruction - diagnostic imaging
Ventricular Outflow Obstruction - physiopathology
Ventricular Outflow Obstruction - therapy
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Summary:Nonsurgical septal reduction therapy (NSRT) decreases left ventricular outflow tract (LVOT) gradient and improves symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). NSRT effects on LV/left ventricular diastolic function are currently unknown. HOCM patients (n=29) had Doppler echocardiography at baseline and 6 months after NSRT to evaluate changes in LV volume, pre-A-wave pressure, early diastolic mitral annulus velocity (Ea) by tissue Doppler, and tau. At 6 months, a significant reduction in LVOT gradient (from 53.6+/-15 to 6+/-5 mm Hg; P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.99.3.344