Anaplastic thyroid carcinoma: A therapeutic challenge

Anaplastic thyroid carcinoma is an extremely aggressive solid tumor that resists most therapeutic efforts and is almost always fatal. It typically arises as a terminal dedifferentiation of unrecognized long‐standing differentiated thyroid carcinoma. Current chemotherapeutic agents are not capable of...

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Bibliographic Details
Published in:Seminars in surgical oncology 1999-01, Vol.16 (1), p.64-69
Main Author: Ain, Kenneth B.
Format: Article
Language:English
Subjects:
anaplasia
carcinoma
Carcinoma - therapy
combined antineoplastic agents
Combined Modality Therapy
differential diagnosis
doxorubicin
drug therapy
Humans
immunohistochemistry
incidence
neoplasm invasiveness
neoplasm metastasis
paclitaxel
prognosis
radiotherapy
thyroid neoplasms
Thyroid Neoplasms - therapy
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Summary:Anaplastic thyroid carcinoma is an extremely aggressive solid tumor that resists most therapeutic efforts and is almost always fatal. It typically arises as a terminal dedifferentiation of unrecognized long‐standing differentiated thyroid carcinoma. Current chemotherapeutic agents are not capable of consistent beneficial therapeutic responses, although rare patients may gain additional months of survival. Aggressive local tumor control with surgery and external beam radiotherapy may provide palliation and delay eventual death from distant metastatic disease. This disease challenges clinicians and researchers to develop new systemic therapies as well as to aggressively treat differentiated thyroid cancers before they become anaplastic tumors.Semin. Surg. Oncol. 16:64–69, 1999. Published 1999 Wiley‐Liss, Inc.
ISSN:8756-0437
1098-2388
DOI:10.1002/(SICI)1098-2388(199901/02)16:1<64::AID-SSU10>3.0.CO;2-U