Serum cystatin C as a determinant of fasting total homocysteine levels in renal transplant recipients with a normal serum creatinine

Serum creatinine, a surrogate for both renal function and homocysteine generation, is an important determinant of fasting plasma total homocysteine levels in stable renal transplant recipients. In this study, it is hypothesized that among stable renal transplant recipients with normal creatinine lev...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Society of Nephrology 1999, Vol.10 (1), p.164-166
Main Authors: BOSTOM, A. G, GOHH, R. Y, BAUSSERMAN, L, HAKAS, D, JACQUES, P. F, SELHUB, J, DWORKIN, L, ROSENBERG, I. H
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Creatinine - blood
Cystatin C
Cystatins - blood
Fasting - blood
Female
Homocysteine - blood
Humans
Kidney Transplantation
Male
Medical sciences
Middle Aged
Statistics as Topic
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Serum creatinine, a surrogate for both renal function and homocysteine generation, is an important determinant of fasting plasma total homocysteine levels in stable renal transplant recipients. In this study, it is hypothesized that among stable renal transplant recipients with normal creatinine levels (i.e., < or = 1.5 mg/dl), serum cystatin C, a more sensitive indicator of GFR, would better predict fasting total homocysteine levels compared with serum creatinine. Fasting plasma total homocysteine, folate, vitamin B12, and pyridoxal 5'-phosphate levels, along with serum cystatin C, creatinine, and albumin levels, were determined in 28 consecutive renal transplant recipients (mean age 47 +/- 14 yr; 60.7% men) with stable allograft function, whose serum creatinine was < or = 1.5 mg/dl. General linear modeling with analysis of covariance revealed that serum cystatin C was independently predictive (partial R = 0.494; P = 0.023) of fasting total homocysteine levels after adjustment for age, gender, vitamin status, albumin, and creatinine levels. In contrast, creatinine levels were not predictive of fasting total homocysteine levels in this model (P = 0.110) or an identical model that excluded cystatin C (P = 0.131). Serum cystatin C levels may reflect subtle decreases in renal function that independently predict fasting total homocysteine levels among stable renal transplant recipients with a normal serum creatinine.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.V101164