Comparison of the effects of two low fat diets with different α-linolenic:linoleic acid ratios on coagulation and fibrinolysis

Fish oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated to alter coagulation and fibrinolysis variables. This study compared the effects of a traditional cholesterol-lowering diet and a similar diet, which had 50% of the linoleic acid (LA) replaced with th...

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Bibliographic Details
Published in:Atherosclerosis 1999-01, Vol.142 (1), p.159-168
Main Authors: Allman-Farinelli, Margaret A., Hall, David, Kingham, Karen, Pang, Dona, Petocz, Peter, Favaloro, Emmanuel J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
alpha-Linolenic Acid - administration & dosage
Biological and medical sciences
Blood Coagulation
Blood Platelets - chemistry
Cholesterol, Dietary - administration & dosage
Coagulation
Diet, Fat-Restricted
Factor VII - analysis
Factor VIII - analysis
Fatty Acids - analysis
Fibrinogen - analysis
Fibrinolysis
Fundamental and applied biological sciences. Psychology
Hemostasis
Humans
Linoleic Acid - administration & dosage
Male
n-3 Fatty acids
Plasminogen Activator Inhibitor 1 - blood
Protein C
Protein C - analysis
Tissue Plasminogen Activator - blood
Tropical medicine
Vertebrates: blood, hematopoietic organs, reticuloendothelial system
von Willebrand Factor - analysis
α-Linolenic acid
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Summary:Fish oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated to alter coagulation and fibrinolysis variables. This study compared the effects of a traditional cholesterol-lowering diet and a similar diet, which had 50% of the linoleic acid (LA) replaced with the 18 carbon n-3 fatty acid, α-linolenic acid (ALA), on selected hemostatic variables. After a 2-week run-in diet with 39.5% total energy (en) from fat, 29 healthy male subjects consumed a 31.5% en fat diet with approximately 7% en from polyunsaturated fat and an ALA:LA ratio of either 1:1.2 (ALA-rich, n=15) or 1:21 (LA-rich, n=14) for 6 weeks. Blood was collected at the beginning, middle and end of test diets for analysis of Factor VIIc and VIIIc, fibrinogen, von Willebrand factor, activated protein C resistance (APC™ resistance), tissue plasminogen activator and plasminogen activator inhibitor type-1 activities and/or protein concentrations and platelet fatty acids. The ALA-rich diet tripled the percentage of platelet EPA, ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(98)00233-0