Diagnostic Value of Ex-Vivo Three-Dimensional Micro-Computed Tomography Imaging of Primary Nonhematopoietic Human Bone Tumors: Osteosarcoma versus Chondrosarcoma

Background: Osteosarcoma and chondrosarcoma are the most common nonhematopoietic primary malignancies of bone. However, unusual radiographic appearances can lead to delay in diagnosis and confusion with benign diseases. Purpose: To evaluate the feasibility of micro-computed tomography (CT) for the a...

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Bibliographic Details
Published in:Acta radiologica (1987) 2008-10, Vol.49 (8), p.940-948
Main Authors: Langheinrich, A. C., Stolle, C., Kampschulte, M., Lommel, D., Rau, W. S., Bassaly, B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Bone and Bones - diagnostic imaging
Bone and Bones - ultrastructure
Bone Neoplasms - diagnosis
Chondrosarcoma - diagnosis
Diagnosis, Differential
Diseases of the osteoarticular system
Feasibility Studies
Female
Humans
Imaging, Three-Dimensional - methods
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Microradiography - methods
Middle Aged
Osteosarcoma - diagnosis
Reproducibility of Results
Tomography, X-Ray Computed - instrumentation
Tomography, X-Ray Computed - methods
Tumors of striated muscle and skeleton
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Summary:Background: Osteosarcoma and chondrosarcoma are the most common nonhematopoietic primary malignancies of bone. However, unusual radiographic appearances can lead to delay in diagnosis and confusion with benign diseases. Purpose: To evaluate the feasibility of micro-computed tomography (CT) for the analysis of primary, nonhematopoietic human bone tumors ex vivo. Material and Methods: Samples from 12 human bone specimens (osteosarcoma, n=6; chondrosarcoma, n=6) obtained for diagnostic purposes were scanned using industrial X-ray film without amplifier foil and scanned with micro-CT (7- and 12-µm-cubic voxels). Trabecular bone CT "density" and tumor matrix CT "density" were determined, and results were compared with those obtained from a detailed conventional histopathologic analysis of corresponding cross-sections. The significance of differences in grayscale measurements was tested with analysis of variance. Results: Micro-CT provided quantitative information on bone morphology equivalent to histopathological analysis. We established grayscale measurements by which tumor matrices of chondrosarcoma and osteosarcoma could be radiographically categorized following histological classifications (P
ISSN:0284-1851
1600-0455
DOI:10.1080/02841850802247673