Mortality of bullous pemphigoid: An evaluation of 223 patients and comparison with the mortality in the general population in the United States

Background There are large discrepancies in reported mortality for bullous pemphigoid (BP). Objective We sought to determine the mortality of a large cohort of patients with BP and compare this with age-matched control subjects. Methods Data were collected on 223 patients with a new diagnosis of BP...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2008-10, Vol.59 (4), p.582-588
Main Authors: Parker, Sareeta R.S., MD, Dyson, Senait, MD, Brisman, Stacey, MD, Pennie, Michelle, MD, Swerlick, Robert A., MD, Khan, Rizwana, BS, MSPH, Manos, Sue, MS, Korman, Benjamin D., BS, Xia, Zongqi, MD, Korman, Neil J., MD, PhD
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Biological and medical sciences
Bullous diseases of the skin
Case-Control Studies
Cause of Death - trends
Cohort Studies
Confidence Intervals
Dermatology
Epidemiology
Female
General aspects
Humans
Male
Medical sciences
Middle Aged
Pemphigoid, Bullous - mortality
Public health. Hygiene
Public health. Hygiene-occupational medicine
Retrospective Studies
Sex Distribution
Survival Rate
United States - epidemiology
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Summary:Background There are large discrepancies in reported mortality for bullous pemphigoid (BP). Objective We sought to determine the mortality of a large cohort of patients with BP and compare this with age-matched control subjects. Methods Data were collected on 223 patients with a new diagnosis of BP between 1998 and 2003 through our cutaneous immunofluorescence laboratory databases. The mortality of patients with BP was compared with that of age-matched control subjects in the general US population. Results The 1-, 2-, and 5-year mortality was 0.23 (95% confidence interval = 0.18, 0.29), 0.37 (95% confidence interval = 0.31, 0.44), and 0.50 (95% confidence interval = 0.42, 0.57), respectively. However, relative to age-matched control subjects, no difference in expected mortality was detected. Limitations This was a retrospective cohort analysis. Conclusions Mortality of patients with BP is more likely related to advanced age and associated medical conditions than to disease-specific factors.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2008.07.022