Low absolute lymphocyte count is a poor prognostic factor in diffuse-large-B-cell-lymphoma

The prognostic value of absolute lymphocytic count (ALC), has been a recent matter of debate in non-Hodgkin-lymphoma (NHL). We assessed prospectively the value of ALC at diagnosis and also after the completion of immuno-chemotherapy in 101 diffuse-large-B-cell-lymphoma (DLBCL). Analysis of prognosti...

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Bibliographic Details
Published in:Leukemia & lymphoma 2008-01, Vol.49 (9), p.1745-1751
Main Authors: Cox, Maria Christina, Nofroni, Italo, Ruco, Luigi, Amodeo, Rachele, Ferrari, Antonella, La Verde, Giacinto, Cardelli, Patrizia, Montefusco, Enrico, Conte, Esmeralda, Monarca, Bruno, Aloe-Spiriti, Maria Antonietta
Format: Article
Language:English
Subjects:
ALC
Analysis of Variance
antibody-based immunotherapy
Female
hematopoiesis
Humans
Lymphocyte Count
lymphocytes
Lymphocytes - pathology
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - mortality
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Middle Aged
Non-Hodgkin lymphoma
Predictive Value of Tests
Prognosis
Prognostication
Prospective Studies
Survival Analysis
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Summary:The prognostic value of absolute lymphocytic count (ALC), has been a recent matter of debate in non-Hodgkin-lymphoma (NHL). We assessed prospectively the value of ALC at diagnosis and also after the completion of immuno-chemotherapy in 101 diffuse-large-B-cell-lymphoma (DLBCL). Analysis of prognostic factors with respect to overall survival (OS), event free survival (EFS) and progression free survival (PFS) was done by two-tailed log-rank test. The ALC cut-off value was calculated as
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190802226425