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Bio-active cardenolides from the leaves of Nerium oleander
A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known...
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| Published in: | Phytochemistry (Oxford) 1999-02, Vol.50 (3), p.435-438 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c389t-ba0a7fba45ae018ee9389c1af0e238dae17d84264f1a14c7cd4190eb00b9ebef3 |
| container_end_page | 438 |
| container_issue | 3 |
| container_start_page | 435 |
| container_title | Phytochemistry (Oxford) |
| container_volume | 50 |
| creator | Begum, Sabira Siddiqui, Bina S Sultana, Razia Zia, Atiya Amin Suria |
| description | A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of
Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25
mg/kg. The structure of neridiginoside was elucidated as 3β-
O-(
d-diginosyl)-5β,14β-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY,
J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature. |
| doi_str_mv | 10.1016/S0031-9422(98)00523-8 |
| format | article |
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Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25
mg/kg. The structure of neridiginoside was elucidated as 3β-
O-(
d-diginosyl)-5β,14β-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY,
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Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25
mg/kg. The structure of neridiginoside was elucidated as 3β-
O-(
d-diginosyl)-5β,14β-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY,
J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature.</description><subject>Animals</subject><subject>Apocynaceae</subject><subject>Biological and medical sciences</subject><subject>cardenolide</subject><subject>Cardenolides - chemistry</subject><subject>Cardenolides - isolation & purification</subject><subject>Cardenolides - pharmacology</subject><subject>Chemical constitution</subject><subject>CNS activity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>neridiginoside</subject><subject>Nerium oleander</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Leaves - chemistry</subject><subject>Plant physiology and development</subject><subject>Plants, Medicinal - chemistry</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkEtr3DAQgEVI2W6T_IQFH0poD25HliVLuZR26QtCekhyFrI0oiq2tZG8C_n3VXaX5JjTMDPfPPgIWVH4RIGKz7cAjNaqbZoPSn4E4A2r5QlZUtmxmnUAp2T5jLwl73L-B4XiQizIQinGFOdLcvUtxNrYOeywsiY5nOIQHObKpzhW81-sBjS7kkdf3WAK27GKpTI5TOfkjTdDxotjPCP3P77frX_V139-_l5_va4tk2quewOm871puUGgElGVsqXGAzZMOoO0c7JtROupoa3trGupAuwBeoU9enZGLg97Nyk-bDHPegzZ4jCYCeM2a6G4AMGggPwA2hRzTuj1JoXRpEdNQT8503tn-kmIVlLvnWlZ5lbHA9t-RPc8dZRU-u-PfZOtGXwykw35ZbkQDW9owb4cMCwydgGTzjbgZNGFhHbWLoZXHvkPOhmIEg</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Begum, Sabira</creator><creator>Siddiqui, Bina S</creator><creator>Sultana, Razia</creator><creator>Zia, Atiya</creator><creator>Amin Suria</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Bio-active cardenolides from the leaves of Nerium oleander</title><author>Begum, Sabira ; Siddiqui, Bina S ; Sultana, Razia ; Zia, Atiya ; Amin Suria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ba0a7fba45ae018ee9389c1af0e238dae17d84264f1a14c7cd4190eb00b9ebef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Apocynaceae</topic><topic>Biological and medical sciences</topic><topic>cardenolide</topic><topic>Cardenolides - chemistry</topic><topic>Cardenolides - isolation & purification</topic><topic>Cardenolides - pharmacology</topic><topic>Chemical constitution</topic><topic>CNS activity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry - methods</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>neridiginoside</topic><topic>Nerium oleander</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Leaves - chemistry</topic><topic>Plant physiology and development</topic><topic>Plants, Medicinal - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begum, Sabira</creatorcontrib><creatorcontrib>Siddiqui, Bina S</creatorcontrib><creatorcontrib>Sultana, Razia</creatorcontrib><creatorcontrib>Zia, Atiya</creatorcontrib><creatorcontrib>Amin Suria</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begum, Sabira</au><au>Siddiqui, Bina S</au><au>Sultana, Razia</au><au>Zia, Atiya</au><au>Amin Suria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bio-active cardenolides from the leaves of Nerium oleander</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>50</volume><issue>3</issue><spage>435</spage><epage>438</epage><pages>435-438</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of
Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25
mg/kg. The structure of neridiginoside was elucidated as 3β-
O-(
d-diginosyl)-5β,14β-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY,
J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>9933955</pmid><doi>10.1016/S0031-9422(98)00523-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 1999-02, Vol.50 (3), p.435-438 |
| issn | 0031-9422 1873-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69560630 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Apocynaceae Biological and medical sciences cardenolide Cardenolides - chemistry Cardenolides - isolation & purification Cardenolides - pharmacology Chemical constitution CNS activity Fundamental and applied biological sciences. Psychology General pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry - methods Medical sciences Mice Molecular Structure neridiginoside Nerium oleander Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plant physiology and development Plants, Medicinal - chemistry |
| title | Bio-active cardenolides from the leaves of Nerium oleander |
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