Plasma Levels of the Interleukin-6 Cytokine Family in Persons with Severe Plasmodium falciparum Malaria

Plasma levels of interleukin (IL)-6, soluble IL-6 receptor, soluble gp130, leukemia inhibitory factor (LIF), and ciliary neutrophic factor (CNTF) were analyzed in 32 patients with severe malaria. Ten had renal failure, 8 had cerebral malaria, and 14 had other causes of severity. Before treatment, th...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-03, Vol.179 (3), p.747-750
Main Authors: Wenisch, Christoph, Linnau, Ken F., Looaresuwan, Sornchai, Rumpold, Helmut
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - immunology
Adolescent
Adult
Animals
Antimalarials - therapeutic use
Artemisinins
Biological and medical sciences
Biomarkers - blood
Blood plasma
Cerebral malaria
Ciliary Neurotrophic Factor
Concise Communications
Cytokines
Falciparum malaria
Female
Human protozoal diseases
Humans
Infectious diseases
Interleukin-6 - blood
Kidney failure
Malaria
Malaria, Cerebral - blood
Malaria, Cerebral - immunology
Malaria, Falciparum - drug therapy
Malaria, Falciparum - immunology
Malaria, Falciparum - physiopathology
Male
Medical sciences
Middle Aged
Nerve Growth Factors - blood
Nerve Tissue Proteins - blood
Nervous system diseases
Parasites
Parasitic diseases
Plasmodium falciparum
Plasmodium falciparum - isolation & purification
Protozoal diseases
Receptors
Receptors, Interleukin-6 - blood
Reference Values
Sesquiterpenes - therapeutic use
Tropical medicine
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Description
Summary:Plasma levels of interleukin (IL)-6, soluble IL-6 receptor, soluble gp130, leukemia inhibitory factor (LIF), and ciliary neutrophic factor (CNTF) were analyzed in 32 patients with severe malaria. Ten had renal failure, 8 had cerebral malaria, and 14 had other causes of severity. Before treatment, the IL-6 and soluble IL-6 receptor plasma levels were significantly higher in persons with cerebral malaria or renal failure than in other groups (P
ISSN:0022-1899
1537-6613
DOI:10.1086/314630