Androgen receptor immunoreactivity in specific neural regions in normal and hypogonadal male mice: effect of androgens

This study examined the distribution and regulation of androgen receptor immunoreactivity (IR) in the brain of the hypogonadal (hpg) male mouse, genetically deficient in GnRH. Five groups of animals were studied: intact, castrated, or castrated and testosterone propionate (TP)-treated normal adult m...

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Bibliographic Details
Published in:Brain research 1999-01, Vol.817 (1-2), p.19-24
Main Authors: Apostolinas, Stergios, Rajendren, Gopalan, Dobrjansky, Areta, Gibson, Marie J.
Format: Article
Language:English
Subjects:
Analysis of Variance
Androgen receptor
Animals
Biological and medical sciences
Brain
Brain - drug effects
Brain - metabolism
Brain Mapping
Castration
Fundamental and applied biological sciences. Psychology
General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions
Gonadotropin-Releasing Hormone - deficiency
Hypogonadal
Hypogonadism - drug therapy
Hypogonadism - metabolism
Immunohistochemistry
Male
Mice
Mice, Inbred C3H
Mouse
Receptors, Androgen - analysis
Reference Values
Regulation
Testis - physiology
Testosterone
Testosterone - pharmacology
Vertebrates: endocrinology
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Summary:This study examined the distribution and regulation of androgen receptor immunoreactivity (IR) in the brain of the hypogonadal (hpg) male mouse, genetically deficient in GnRH. Five groups of animals were studied: intact, castrated, or castrated and testosterone propionate (TP)-treated normal adult male mice, and intact or TP-treated hpg adult male mice. All groups were studied 1 week after treatment. Five regions of the brain with high concentrations of androgen receptors in normal animals were examined, including the medial preoptic area, the lateral ventral septum, the ventromedial hypothalamus, the bed nucleus of the stria terminalis and the medial amygdala. The results showed that the congenital absence of GnRH results in minimal expression of androgen receptor-IR in mice in all regions examined. However, treatment with exogenous testosterone for 1 week was sufficient to induce the numbers of neurons containing androgen receptors, as detected by immunocytochemistry, into the range seen in normal male mice in all the areas studied except the VMH. Similar plasticity was also observed in normal males after 1 week of castration and TP replacement.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)01180-9