Comparative Study of Carbohydrate Antigen 195 and Carcinoembryonic Antigen for the Diagnosis of Pancreatic Carcinoma

p < 0.001). Sensitivity was increased to 92.5% with the simultaneous use of the two antigens, but the difference was statistically significant only with CEA (p < 0.001). The specificity of CA195 calculated from all patients with benign diseases was lower than that of CEA (73.1% vs. 89.8%). How...

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Bibliographic Details
Published in:World journal of surgery 1999-03, Vol.23 (3), p.227-232
Main Authors: Andicoechea, Alejandro, Vizoso, Francisco, Alexandre, Enrique, Martínez, Aránzazu, Díez, María Cruz, Riera, Luis, Martinez, Enrique, Ruibal, Alvaro
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Antigens, Tumor-Associated, Carbohydrate - blood
Carbohydrate
Carcinoembryonic Antigen - blood
Carcinoma
Humans
Immunoradiometric Assay
Pancreatic Cancer
Pancreatic Carcinoma
Pancreatic Diseases - diagnosis
Pancreatic Neoplasms - diagnosis
Predictive Value of Tests
Sensitivity and Specificity
Statistics, Nonparametric
Tumor Antigen
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Summary:p < 0.001). Sensitivity was increased to 92.5% with the simultaneous use of the two antigens, but the difference was statistically significant only with CEA (p < 0.001). The specificity of CA195 calculated from all patients with benign diseases was lower than that of CEA (73.1% vs. 89.8%). However, using a cutoff value of 100 U/ml for CA195, the specificity of this antigen (82%) was higher than that of CEA. These results demonstrate that marked elevations of tumor antigen CA195 are relatively specific for pancreatic carcinoma, and that this antigen is superior to CEA for diagnosing pancreatic cancer by virtue of its higher sensitivity.
ISSN:0364-2313
1432-2323
DOI:10.1007/PL00013182