Is pleomorphic lobular carcinoma really a distinct clinical entity?

Background Attempts to define the clinical behavior of pleomorphic lobular carcinoma (PLC) have been limited to small series, and clinical management strategies have yet to be established. We describe our experience with PLC as compared to classic ILC and invasive ductal carcinoma (IDC). Methods Fro...

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Bibliographic Details
Published in:Journal of surgical oncology 2008-10, Vol.98 (5), p.314-317
Main Authors: Buchanan, Claire L., Flynn, Laurie W., Murray, Melissa P., Darvishian, Farbod, Cranor, Milicent L., Fey, Jane V., King, Tari A., Tan, Lee K., Sclafani, Lisa M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - therapy
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - therapy
Carcinoma, Lobular - pathology
Carcinoma, Lobular - therapy
classic lobular carcinoma
Female
Humans
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
pleomorphic lobular carcinoma
recurrence
Sentinel Lymph Node Biopsy
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Summary:Background Attempts to define the clinical behavior of pleomorphic lobular carcinoma (PLC) have been limited to small series, and clinical management strategies have yet to be established. We describe our experience with PLC as compared to classic ILC and invasive ductal carcinoma (IDC). Methods From 9/1996 to 5/2003, clinical and histopathologic data for 5,635 patients undergoing primary surgical treatment and sentinel lymph node biopsy for breast cancer were collected. Four hundred eighty one (8.5%) patients were diagnosed with ILC; 3,978 (70.6%) with IDC. Of those with ILC, 356 (74%) patients had material available for pathologic re‐review and comprise our study population: 52 were classified as PLC; 298 were classified as classic ILC; and 6 cases were reclassified as IDC. We compared clinical, pathologic, and treatment factors for patients with PLC, ILC, and IDC using the Wilcoxon rank sum and Fisher's exact tests. Results PLC were larger than ILC and IDC (20 vs. 15 vs. 13, P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21121