Trovafloxacin: An Overview

Trovafloxacin, a new synthetic naphthyridine fluoroquinolone antibiotic, is a broad‐spectrum agent available orally and intravenously. It was recently approved by the Food and Drug Administration for the treatment of selected pulmonary, surgical, intraabdominal, gynecologic, pelvic, skin, and urinar...

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Bibliographic Details
Published in:Pharmacotherapy 1999-01, Vol.19 (1), p.21-34
Main Authors: Garey, Kevin W., Amsden, Guy W.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - drug therapy
Biological and medical sciences
Clinical Trials as Topic
Fluoroquinolones
Humans
Medical sciences
Multicenter Studies as Topic
Naphthyridines - pharmacokinetics
Naphthyridines - therapeutic use
Pharmacology. Drug treatments
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Summary:Trovafloxacin, a new synthetic naphthyridine fluoroquinolone antibiotic, is a broad‐spectrum agent available orally and intravenously. It was recently approved by the Food and Drug Administration for the treatment of selected pulmonary, surgical, intraabdominal, gynecologic, pelvic, skin, and urinary tract infections. Its spectrum of activity includes aerobic gram‐positive and gram‐negative organisms as well as anaerobic pathogens. It is rapidly absorbed after oral administration, achieves good tissue and cerebrospinal fluid penetration, and has a half‐life that allows once‐daily dosing. It is hepatically metabolized, and dosage adjustments are necessary for patients with severe hepatic dysfunction but not for those with mild or moderate dysfunction or renal dysfunction. The drug has a favorable safety profile, and a high tendency for transient first‐dose dizziness and/or lightheadedness in young women. Similar to other quinolones, trovafloxacin should not be taken with antacids that contain aluminum or magnesium, sucralfate, or ferrous sulfate. Trovafloxacin may prove beneficial as it allows for oral or intravenous monotherapy against indicated infections that normally require multidrug, broad‐spectrum antibiotic coverage.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.19.1.21.30507