Limited Nonrandom Chromosomal Aberrations in a Recurrent Adenoid Cystic Carcinoma of the Parotid Gland

We present the cytogenetic, interphase fluorescence in-situ hybridization (FISH) and DNA content findings in a clinically aggressive adenoid cystic carcinoma (ADCC) of the parotid gland. The tumor manifested diploid chromosomal and DNA content by cytogenetic, interphase FISH and flow cytometry. G-ba...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1999-02, Vol.109 (1), p.66-69
Main Authors: El-Naggar, Adel K, Lovell, Mercedes, Callender, David L, Killary, Ann M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma, Adenoid Cystic - genetics
Carcinoma, Adenoid Cystic - pathology
Carcinoma, Adenoid Cystic - surgery
Chromosome Aberrations
Chromosome Banding
Chromosome Inversion
Chromosome Mapping
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 6
Humans
Karyotyping
Male
Medical sciences
Otorhinolaryngology. Stomatology
Parotid Neoplasms - genetics
Parotid Neoplasms - pathology
Parotid Neoplasms - surgery
Recurrence
Translocation, Genetic
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:We present the cytogenetic, interphase fluorescence in-situ hybridization (FISH) and DNA content findings in a clinically aggressive adenoid cystic carcinoma (ADCC) of the parotid gland. The tumor manifested diploid chromosomal and DNA content by cytogenetic, interphase FISH and flow cytometry. G-banding analysis revealed inv(5)(p15.2q33) and t(6;15)(q25;q15) as the only structural alterations in all 30 metaphases examined. The limited structural abnormalities found in this recurrent lesion suggest that they may constitute a primary or early event in the development of this tumor. The involvement of 6q region in our tumor and in some of the previously reported ADCC supports the association between this region and the evolution of at least a subset of these tumors.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(98)00188-5