F4 ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease

• Published in: Journal of neurochemistry 1999-02, Vol.72 (2), p.734-740
• Main Authors: Nourooz‐Zadeh, Jaffar, Liu, Edwin H. C., Yhlen, B., Änggåard, Erik E., Halliwell, Barry
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - metabolism; Alzheimer's disease; Arachidonic acid; Arachidonic Acid - analysis; Arachidonic Acid - chemistry; Biological and medical sciences; Biomarkers; Brain Chemistry; Cerebral Cortex - chemistry; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Docosahexaenoic acid; Docosahexaenoic Acids - analysis; Docosahexaenoic Acids - chemistry; Eicosapentaenoic Acid - analysis; Eicosapentaenoic Acid - chemistry; Esters - analysis; Gas Chromatography-Mass Spectrometry; Humans; Isoprostanes; Lipid peroxidation; Lipid Peroxidation - physiology; Lipids - analysis; Medical sciences; Neurology
• ISSN: 0022-3042; 1471-4159
• DOI: 10.1046/j.1471-4159.1999.0720734.x

: F2‐isoprostanes are prostaglandin‐like compounds derived from free radical‐catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F3‐isoprostanes, whereas peroxidation of docosahexaenoic acid would give F4‐isoprostanes. This study demonstrates the presence of esterified F4‐isoprostanes in human brain and shows that levels are elevated in certain brain cortex regions in Alzheimer's disease. Our data with Alzheimer's disease suggest that analysis of F4‐isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.