Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has...

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Bibliographic Details
Published in:Pediatric and developmental pathology 2008-07, Vol.11 (4), p.300-304
Main Authors: Hall, Odette R., Pascasio, Judy M., Morrissette, Jennifer J., Newton, Christopher, Schwartz, Marshall Z., de Chadarévian, Jean-Pierre
Format: Article
Language:English
Subjects:
Cell Proliferation
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Infant
Ovarian Neoplasms - chemistry
Ovarian Neoplasms - complications
Ovarian Neoplasms - diagnosis
Ovariectomy
Sex Cord-Gonadal Stromal Tumors - chemistry
Sex Cord-Gonadal Stromal Tumors - complications
Sex Cord-Gonadal Stromal Tumors - diagnosis
Stromal Cells - pathology
Ubiquitin-Protein Ligases - analysis
Uterine Hemorrhage - diagnosis
Uterine Hemorrhage - etiology
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Summary:This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has been subject to debate. In addition, it has been rarely seen in children and never in infants, with the youngest patient reported being 10 years of age. Histological study of the tumor showed a process of multinodular asynchronous growth followed by gradual loss of cells, hyalinization, and eventual transformation into corpora albicantia–like structures, thus indicating that the process may be more akin to an ovarian nodular follicular hyperplasia than to a classical neoplasm. The study also documented an elevated proliferative MIB-1 index in the process, which had not been investigated in earlier reports, and illustrated the immunohistochemical reactivity of some of its stromal cells to progesterone receptors.
ISSN:1093-5266
1615-5742
DOI:10.2350/07-05-0281.1