Undetectable inhibin B serum levels in men after testicular irradiation

A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirtee...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 1999, Vol.84 (1), p.213-215
Main Authors: PETERSEN, P. M, ANDERSSON, A.-M, RØRTH, M, DAUGAARD, G, SKAKKEBAEK, N. E
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma in Situ - blood
Carcinoma in Situ - radiotherapy
Follicle Stimulating Hormone - blood
Genital system. Mammary gland
Humans
Inhibins - blood
Luteinizing Hormone - blood
Male
Medical sciences
Middle Aged
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Testicular Neoplasms - blood
Testicular Neoplasms - radiotherapy
Testis - radiation effects
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Summary:A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirteen men with verified spermatogenesis and detectable preirradiation levels of serum inhibin B (median, 55; range, 23-193 pg/mL) were investigated before and after testicular irradiation (14-20 Gy). All patients had undetectable levels of inhibin B 2-12 months (median, 5 months) after radiotherapy (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.84.1.213