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Undetectable inhibin B serum levels in men after testicular irradiation
A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirtee...
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Published in: | The journal of clinical endocrinology and metabolism 1999, Vol.84 (1), p.213-215 |
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container_title | The journal of clinical endocrinology and metabolism |
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creator | PETERSEN, P. M ANDERSSON, A.-M RØRTH, M DAUGAARD, G SKAKKEBAEK, N. E |
description | A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirteen men with verified spermatogenesis and detectable preirradiation levels of serum inhibin B (median, 55; range, 23-193 pg/mL) were investigated before and after testicular irradiation (14-20 Gy). All patients had undetectable levels of inhibin B 2-12 months (median, 5 months) after radiotherapy ( |
doi_str_mv | 10.1210/jc.84.1.213 |
format | article |
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M ; ANDERSSON, A.-M ; RØRTH, M ; DAUGAARD, G ; SKAKKEBAEK, N. E</creator><creatorcontrib>PETERSEN, P. M ; ANDERSSON, A.-M ; RØRTH, M ; DAUGAARD, G ; SKAKKEBAEK, N. E</creatorcontrib><description>A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirteen men with verified spermatogenesis and detectable preirradiation levels of serum inhibin B (median, 55; range, 23-193 pg/mL) were investigated before and after testicular irradiation (14-20 Gy). All patients had undetectable levels of inhibin B 2-12 months (median, 5 months) after radiotherapy (<20 pg/mL). Correspondingly, serum FSH increased in all men after radiotherapy [from a median of 9.6 (range, 3.0-24) IU/L to a median of 28 (range, 15-70) IU/L); P < 0.001]. Histological investigation showed a Sertoli cell-only pattern in all patients after radiotherapy. Neither LH nor testosterone showed a significant decrease after radiotherapy. Our data indicate that inhibin B production sufficient to maintain detectable serum levels in adults requires spermatogenic activity.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.84.1.213</identifier><identifier>PMID: 9920086</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Biological and medical sciences ; Carcinoma in Situ - blood ; Carcinoma in Situ - radiotherapy ; Follicle Stimulating Hormone - blood ; Genital system. Mammary gland ; Humans ; Inhibins - blood ; Luteinizing Hormone - blood ; Male ; Medical sciences ; Middle Aged ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Testicular Neoplasms - blood ; Testicular Neoplasms - radiotherapy ; Testis - radiation effects</subject><ispartof>The journal of clinical endocrinology and metabolism, 1999, Vol.84 (1), p.213-215</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-b50bcde9d447ad83b098b3d90f8bd8c0775de445819034a8ba7d5bbc06dcdf5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1649518$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9920086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PETERSEN, P. M</creatorcontrib><creatorcontrib>ANDERSSON, A.-M</creatorcontrib><creatorcontrib>RØRTH, M</creatorcontrib><creatorcontrib>DAUGAARD, G</creatorcontrib><creatorcontrib>SKAKKEBAEK, N. E</creatorcontrib><title>Undetectable inhibin B serum levels in men after testicular irradiation</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirteen men with verified spermatogenesis and detectable preirradiation levels of serum inhibin B (median, 55; range, 23-193 pg/mL) were investigated before and after testicular irradiation (14-20 Gy). All patients had undetectable levels of inhibin B 2-12 months (median, 5 months) after radiotherapy (<20 pg/mL). Correspondingly, serum FSH increased in all men after radiotherapy [from a median of 9.6 (range, 3.0-24) IU/L to a median of 28 (range, 15-70) IU/L); P < 0.001]. Histological investigation showed a Sertoli cell-only pattern in all patients after radiotherapy. Neither LH nor testosterone showed a significant decrease after radiotherapy. Our data indicate that inhibin B production sufficient to maintain detectable serum levels in adults requires spermatogenic activity.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinoma in Situ - blood</subject><subject>Carcinoma in Situ - radiotherapy</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Inhibins - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Diet therapy and various other treatments (general aspects)</topic><topic>Testicular Neoplasms - blood</topic><topic>Testicular Neoplasms - radiotherapy</topic><topic>Testis - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PETERSEN, P. M</creatorcontrib><creatorcontrib>ANDERSSON, A.-M</creatorcontrib><creatorcontrib>RØRTH, M</creatorcontrib><creatorcontrib>DAUGAARD, G</creatorcontrib><creatorcontrib>SKAKKEBAEK, N. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Undetectable inhibin B serum levels in men after testicular irradiation</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1999</date><risdate>1999</risdate><volume>84</volume><issue>1</issue><spage>213</spage><epage>215</epage><pages>213-215</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male. Thirteen men with verified spermatogenesis and detectable preirradiation levels of serum inhibin B (median, 55; range, 23-193 pg/mL) were investigated before and after testicular irradiation (14-20 Gy). All patients had undetectable levels of inhibin B 2-12 months (median, 5 months) after radiotherapy (<20 pg/mL). Correspondingly, serum FSH increased in all men after radiotherapy [from a median of 9.6 (range, 3.0-24) IU/L to a median of 28 (range, 15-70) IU/L); P < 0.001]. Histological investigation showed a Sertoli cell-only pattern in all patients after radiotherapy. Neither LH nor testosterone showed a significant decrease after radiotherapy. Our data indicate that inhibin B production sufficient to maintain detectable serum levels in adults requires spermatogenic activity.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>9920086</pmid><doi>10.1210/jc.84.1.213</doi><tpages>3</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Carcinoma in Situ - blood Carcinoma in Situ - radiotherapy Follicle Stimulating Hormone - blood Genital system. Mammary gland Humans Inhibins - blood Luteinizing Hormone - blood Male Medical sciences Middle Aged Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Testicular Neoplasms - blood Testicular Neoplasms - radiotherapy Testis - radiation effects |
title | Undetectable inhibin B serum levels in men after testicular irradiation |
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