Histopathological and Immunohistochemical Studies of Lesions Associated with Ebola Virus in a Naturally Infected Chimpanzee

Lesions caused by the Côte d'Ivoire subtype of Ebola virus in a naturally infected young chimpanzee were characterized by histopathological and immunohistochemical methods. The predominant lesions consisted of multifocal necrosis in the liver and diffuse fibrinoid necrosis in the red pulp of th...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-02, Vol.179 (Supplement-1), p.S54-S59
Main Authors: Wyers, M., Formenty, P., Cherel, Y., Guigand, L., Fernandez, B., Boesch, C., Le Guenno, B.
Format: Article
Language:English
Subjects:
Animals
Animals, Wild
Antibodies
Antigens, Viral - metabolism
Ape Diseases - immunology
Ape Diseases - pathology
Ape Diseases - virology
Clinical Observations
Cote d'Ivoire
Cytoplasm
Ebola virus
Ebolavirus - classification
Ebolavirus - immunology
Ebolavirus - isolation & purification
Female
Hemorrhagic Fever, Ebola - etiology
Hemorrhagic Fever, Ebola - pathology
Hemorrhagic Fever, Ebola - veterinary
Hepatocytes
Immunohistochemistry
Inclusion bodies
Inclusion Bodies, Viral - pathology
Inclusion Bodies, Viral - virology
Lesions
Liver - pathology
Liver - virology
Macrophages
Macrophages - pathology
Macrophages - virology
Pan troglodytes
Parenchyma
Spleen - pathology
Spleen - virology
Viral antigens
Viruses
Citations: Items that cite this one
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Summary:Lesions caused by the Côte d'Ivoire subtype of Ebola virus in a naturally infected young chimpanzee were characterized by histopathological and immunohistochemical methods. The predominant lesions consisted of multifocal necrosis in the liver and diffuse fibrinoid necrosis in the red pulp of the spleen. In these sites, macrophages contained large eosinophilic intracytoplasmic inclusion bodies. Immunohistochemical staining indicated that macrophages were a major site of viral replication. The absence of bronchiolar and pulmonary lesions and the paucity of antigen-containing macrophages in the lung suggested that aerosol transmission by this animal was unlikely. There were necrotic foci and antigen-containing macrophages in intestinal lymph nodes, in association with lesions caused by intestinal parasites, suggesting the possibility of virus entry through the digestive tract.
ISSN:0022-1899
1537-6613
DOI:10.1086/514300