Indirect Effect of 7-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Colonization among Unvaccinated Household Members

Background. Since the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in the United States, rates of invasive pneumococcal disease have decreased in both vaccinated and unvaccinated age groups. Reduction of invasive pneumococcal disease in unvaccinated groups has been attributed to re...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-10, Vol.47 (8), p.989-996
Main Authors: Millar, Eugene V., Watt, James P., Bronsdon, Melinda A., Dallas, Jean, Reid, Raymond, Santosham, Mathuram, O'Brien, Katherine L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age groups
Aged
Aged, 80 and over
Articles and Commentaries
Carrier State - epidemiology
Carrier State - microbiology
Carrier State - prevention & control
Child
Child, Preschool
Children
Children & youth
Clinical trials
Clinical Trials as Topic
Communities
Conjugate vaccines
Disease transmission
Effects
Epidemiology
Experimentation
Family Characteristics
Family Health
Female
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Infant
Infants
Infectious diseases
Male
Meningococcal Vaccines - immunology
Middle Aged
Nasopharynx - microbiology
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - immunology
Prevalence
Serotyping
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - isolation & purification
United States - epidemiology
Vaccination
Vaccines
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Description
Summary:Background. Since the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in the United States, rates of invasive pneumococcal disease have decreased in both vaccinated and unvaccinated age groups. Reduction of invasive pneumococcal disease in unvaccinated groups has been attributed to reduced transmission of vaccine-type pneumococci in the community. Understanding the impact of PCV7 on carriage among vaccinated and unvaccinated community members is critical to interpreting, predicting, and understanding the impact of PCV7 on disease. Methods. A group-randomized, phase III efficacy trial of PCV7 was conducted among southwestern American Indian communities. Meningococcal conjugate vaccine against serogroup C was used as the control. After the trial was unblinded, we conducted a carriage study of participating communities to evaluate the impact of PCV7 on colonization among trial participants and their unvaccinated household members. Results. Adults and unvaccinated children aged
ISSN:1058-4838
1537-6591
DOI:10.1086/591966