Sample size formula with a continuous outcome for unequal group sizes and unequal variances

Guenther derived a simple formula for the accurate computation of equal sample sizes when the two‐sample t‐test with pooled variance estimate is used. In the present paper, the Guenther formula is generalized to the case of unequal sample sizes. In addition, the case of unequal variances is consider...

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Bibliographic Details
Published in:Statistics in medicine 1999-01, Vol.18 (1), p.87-91
Main Author: Schouten, Hubert J. A.
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Computerized, statistical medical data processing and models in biomedicine
Humans
Medical sciences
Medical statistics
Patients
Sample Size
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Summary:Guenther derived a simple formula for the accurate computation of equal sample sizes when the two‐sample t‐test with pooled variance estimate is used. In the present paper, the Guenther formula is generalized to the case of unequal sample sizes. In addition, the case of unequal variances is considered. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:0277-6715
1097-0258
DOI:10.1002/(SICI)1097-0258(19990115)18:1<87::AID-SIM958>3.0.CO;2-K